General Information:

Id: 2,831
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Hundal RS et al.(2000) Mechanism by which metformin reduces glucose production in type 2 diabetes. Diabetes 49: 2063-2069 [PMID: 11118008]

Interaction Information:

Comment The rate of glucose production was twice as high in the diabetic subjects as in control subjects.
Formal Description
Interaction-ID: 26125

increases_activity of

process

hepatic glucose production

in liver
Comment Metformin reduced that rate of glucose production by 24% and fasting plasma glucose concentration by 30%.
Formal Description
Interaction-ID: 26127

drug/chemical compound

Metformin

decreases_activity of

process

hepatic glucose production

in liver
Drugbank entries Show/Hide entries for Metformin
Comment Metformin reduced that rate of glucose production by 24% and fasting plasma glucose concentration by 30%.
Formal Description
Interaction-ID: 26128

drug/chemical compound

Metformin

decreases_activity of

phenotype

hyperglycemia

in blood plasma; after fasting
Drugbank entries Show/Hide entries for Metformin
Comment The rate of gluconeogenesis was three times higher in the diabetic subjects than in the control subjects and metformin reduced that rate by 36%.
Formal Description
Interaction-ID: 26130

increases_activity of

process

gluconeogenesis

in liver
Comment The rate of gluconeogenesis was three times higher in the diabetic subjects than in the control subjects and metformin reduced that rate by 36%.
Formal Description
Interaction-ID: 26131

drug/chemical compound

Metformin

decreases_activity of

process

gluconeogenesis

in liver
Drugbank entries Show/Hide entries for Metformin
Comment Both gluconeogenesis and glycogenolysis contribute to hepatic glucose production.
Formal Description
Interaction-ID: 26132

process

gluconeogenesis

increases_activity of

process

hepatic glucose production

in liver
Comment Both gluconeogenesis and glycogenolysis contribute to hepatic glucose production.
Formal Description
Interaction-ID: 26134

increases_activity of

process

hepatic glucose production

in liver