General Information:

Id: 2,786 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Dao TM et al.(2011) Resveratrol increases glucose induced GLP-1 secretion in mice: a mechanism which contributes to the glycemic control. PLoS ONE 6 [PMID: 21673955]

Interaction Information:

Comment Resveratrol (RSV) treatment decreased the inflammatory status of mice. RSV markedly increased IL-10 expression in the colon, liver, and muscle by 3.1, 3.7 and 1.7-fold, respectively. TGF-beta levels were also significantly increased in response to RSV. Conversely, RSV induced a significant decrease of TNF-alpha expression in the same three tissues. In brain the expression level of proglucagon, IL-10 and PAI-1 was evaluated. The results indicated that RSV did not modify the proglucagon mRNA level. In contrast, the PAI-1 mRNA level was decreased (3.5 fold) when RSV was added in HFD compared to HFD. IL-10 mRNA level significantly increased (2.1 fold) in HFD + RSV compared to HFD.
Formal Description
Interaction-ID: 25764

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

TNF

in colon, in liver, in muscle
Drugbank entries Show/Hide entries for Resveratrol or TNF