General Information:

Id: 2,786 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Dao TM et al.(2011) Resveratrol increases glucose induced GLP-1 secretion in mice: a mechanism which contributes to the glycemic control. PLoS ONE 6 [PMID: 21673955]

Interaction Information:

Comment Administration of resveratrol for 5 weeks reduced the development of glucose intolerance, and increased portal vein concentrations of both glucagon-like peptid-1 (GLP-1) and insulin, and intestinal content of active GLP-1.
Formal Description
Interaction-ID: 25746

drug/chemical compound

Resveratrol

increases_quantity of

in blood, in intestine
Drugbank entries Show/Hide entries for Resveratrol
Comment Administration of resveratrol for 5 weeks reduced the development of glucose intolerance, and increased portal vein concentrations of both glucagon-like peptid-1 (GLP-1) and insulin, and intestinal content of active GLP-1.
Formal Description
Interaction-ID: 25755

drug/chemical compound

Resveratrol

increases_quantity of

complex/PPI

Insulin

in blood
Drugbank entries Show/Hide entries for Resveratrol
Comment Administration of resveratrol for 5 weeks reduced the development of glucose intolerance, and increased portal vein concentrations of both glucagon-like peptid-1 (GLP-1) and insulin, and intestinal content of active GLP-1.
Formal Description
Interaction-ID: 25756

drug/chemical compound

Resveratrol

decreases_activity of

in blood
Drugbank entries Show/Hide entries for Resveratrol
Comment Administration of resveratrol for 5 weeks was associated with increased levels of colonic proglucagon mRNA transcripts.
Formal Description
Interaction-ID: 25757

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

GCG

in intestine
Drugbank entries Show/Hide entries for Resveratrol
Comment Resveratrol (RSV)-mediated glucoregulation required a functional GLP-1 receptor (Glp1r) as neither glucose nor insulin levels were modulated in Glp1r-/- mice. Conversely, levels of active GLP-1 and control of glycemia were further improved when the Dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin was co-administered with RSV.
Formal Description
Interaction-ID: 25758

drug/chemical compound

Resveratrol

affects_activity of

via GLP1R
Drugbank entries Show/Hide entries for Resveratrol
Comment Resveratrol (RSV) treatment modified gut microbiota, in particular Parabacteroides jonsonii DMS 18315, Alistipes putredinis DMS 17216, and Bacteroides vulgatus ATCC 8482 disappeared.
Formal Description
Interaction-ID: 25760

drug/chemical compound

Resveratrol

affects_activity of

environment

gut flora

in intestine, in cecum
Drugbank entries Show/Hide entries for Resveratrol
Comment Resveratrol (RSV) treatment decreased the inflammatory status of mice. RSV markedly increased IL-10 expression in the colon, liver, and muscle by 3.1, 3.7 and 1.7-fold, respectively. TGF-beta levels were also significantly increased in response to RSV. Conversely, RSV induced a significant decrease of TNF-alpha expression in the same three tissues. In brain the expression level of proglucagon, IL-10 and PAI-1 was evaluated. The results indicated that RSV did not modify the proglucagon mRNA level. In contrast, the PAI-1 mRNA level was decreased (3.5 fold) when RSV was added in HFD compared to HFD. IL-10 mRNA level significantly increased (2.1 fold) in HFD + RSV compared to HFD.
Formal Description
Interaction-ID: 25761

drug/chemical compound

Resveratrol

decreases_activity of

Drugbank entries Show/Hide entries for Resveratrol
Comment Resveratrol (RSV) treatment decreased the inflammatory status of mice. RSV markedly increased IL-10 expression in the colon, liver, and muscle by 3.1, 3.7 and 1.7-fold, respectively. TGF-beta levels were also significantly increased in response to RSV. Conversely, RSV induced a significant decrease of TNF-alpha expression in the same three tissues. In brain the expression level of proglucagon, IL-10 and PAI-1 was evaluated. The results indicated that RSV did not modify the proglucagon mRNA level. In contrast, the PAI-1 mRNA level was decreased (3.5 fold) when RSV was added in HFD compared to HFD. IL-10 mRNA level significantly increased (2.1 fold) in HFD + RSV compared to HFD.
Formal Description
Interaction-ID: 25762

drug/chemical compound

Resveratrol

increases_expression of

gene/protein

IL10

in colon, in liver, in muscle, in brain
Drugbank entries Show/Hide entries for Resveratrol
Comment Resveratrol (RSV) treatment decreased the inflammatory status of mice. RSV markedly increased IL-10 expression in the colon, liver, and muscle by 3.1, 3.7 and 1.7-fold, respectively. TGF-beta levels were also significantly increased in response to RSV. Conversely, RSV induced a significant decrease of TNF-alpha expression in the same three tissues. In brain the expression level of proglucagon, IL-10 and PAI-1 was evaluated. The results indicated that RSV did not modify the proglucagon mRNA level. In contrast, the PAI-1 mRNA level was decreased (3.5 fold) when RSV was added in HFD compared to HFD. IL-10 mRNA level significantly increased (2.1 fold) in HFD + RSV compared to HFD.
Formal Description
Interaction-ID: 25763

drug/chemical compound

Resveratrol

increases_expression of

gene/protein

TGFB1

in colon, in liver, in muscle
Drugbank entries Show/Hide entries for Resveratrol or TGFB1
Comment Resveratrol (RSV) treatment decreased the inflammatory status of mice. RSV markedly increased IL-10 expression in the colon, liver, and muscle by 3.1, 3.7 and 1.7-fold, respectively. TGF-beta levels were also significantly increased in response to RSV. Conversely, RSV induced a significant decrease of TNF-alpha expression in the same three tissues. In brain the expression level of proglucagon, IL-10 and PAI-1 was evaluated. The results indicated that RSV did not modify the proglucagon mRNA level. In contrast, the PAI-1 mRNA level was decreased (3.5 fold) when RSV was added in HFD compared to HFD. IL-10 mRNA level significantly increased (2.1 fold) in HFD + RSV compared to HFD.
Formal Description
Interaction-ID: 25764

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

TNF

in colon, in liver, in muscle
Drugbank entries Show/Hide entries for Resveratrol or TNF
Comment Resveratrol (RSV) treatment decreased the inflammatory status of mice. RSV markedly increased IL-10 expression in the colon, liver, and muscle by 3.1, 3.7 and 1.7-fold, respectively. TGF-beta levels were also significantly increased in response to RSV. Conversely, RSV induced a significant decrease of TNF-alpha expression in the same three tissues. In brain the expression level of proglucagon, IL-10 and PAI-1 was evaluated. The results indicated that RSV did not modify the proglucagon mRNA level. In contrast, the PAI-1 mRNA level was decreased (3.5 fold) when RSV was added in HFD compared to HFD. IL-10 mRNA level significantly increased (2.1 fold) in HFD + RSV compared to HFD.
Formal Description
Interaction-ID: 25765

drug/chemical compound

Resveratrol

NOT affects_expression of

gene/protein

GCG

in brain
Drugbank entries Show/Hide entries for Resveratrol
Comment Resveratrol (RSV) treatment decreased the inflammatory status of mice. RSV markedly increased IL-10 expression in the colon, liver, and muscle by 3.1, 3.7 and 1.7-fold, respectively. TGF-beta levels were also significantly increased in response to RSV. Conversely, RSV induced a significant decrease of TNF-alpha expression in the same three tissues. In brain the expression level of proglucagon, IL-10 and PAI-1 was evaluated. The results indicated that RSV did not modify the proglucagon mRNA level. In contrast, the PAI-1 mRNA level was decreased (3.5 fold) when RSV was added in HFD compared to HFD. IL-10 mRNA level significantly increased (2.1 fold) in HFD + RSV compared to HFD.
Formal Description
Interaction-ID: 25766

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

SERPINE1

in brain
Drugbank entries Show/Hide entries for Resveratrol or SERPINE1
Comment Resveratrol (RSV) increases GLP-1 production and requires the GLP-1 receptor to mediate its anti-diabetic effect in HFD-induced diabetic mice.
Formal Description
Interaction-ID: 25767

drug/chemical compound

Resveratrol

decreases_activity of

via GLP-1 and GLP1R
Drugbank entries Show/Hide entries for Resveratrol