General Information:

Id: 2,784 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Maida A et al.(2011) Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-alpha in mice. Diabetologia 54: 339-349 [PMID: 20972533]

Interaction Information:

Comment Levels of mRNA transcripts for Glp1r, Gipr and Ppar-alpha were significantly increased in islets from metformin-treated mice.
Formal Description
Interaction-ID: 25738

drug/chemical compound

Metformin

increases_expression of

gene/protein

PPARA

in pancreas, in pancreatic islets
Drugbank entries Show/Hide entries for Metformin or PPARA