General Information:

Id: 2,743
Diseases: Alzheimer disease - [OMIM]
Mus musculus
article
Reference: Lu P et al.(2009) Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice Br. J. Pharmacol. 157: 1270-1277 [PMID: 19552690]

Interaction Information:

Comment Silibinin (also known as silybin) is a flavonoid derived from the herb milk thistle. It prevents memory impairment and oxidative damage induced by aggregated amyloid beta peptides (25-35) in mice and attenuated the amyloid beta (25-35)-induced accumulation of malondialdehyde and depletion of glutathione in the hippocampus.
Formal Description
Interaction-ID: 25399

drug/chemical compound

Silibinin

decreases_activity of

phenotype

Amyloid beta peptide (25-35)-induced memory impairment

Comment Silibinin (also known as silybin) is a flavonoid derived from the herb milk thistle. It prevents memory impairment and oxidative damage induced by aggregated amyloid beta peptides (25-35) in mice and attenuated the amyloid beta (25-35)-induced accumulation of malondialdehyde and depletion of glutathione in the hippocampus.
Formal Description
Interaction-ID: 25402

drug/chemical compound

Silibinin

affects_activity of

Comment Silibinin (also known as silybin) is a flavonoid derived from the herb milk thistle. It prevents memory impairment and oxidative damage induced by aggregated amyloid beta peptides (25-35) in mice and attenuated the amyloid beta (25-35)-induced accumulation of malondialdehyde and depletion of glutathione in the hippocampus.
Formal Description
Interaction-ID: 25417

drug/chemical compound

Silibinin

decreases_quantity of

drug/chemical compound

Malonaldehyde

amyloid beta (25-35)-induced accumulation of malondialdehyde
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Comment Silibinin (also known as silybin) is a flavonoid derived from the herb milk thistle. It prevents memory impairment and oxidative damage induced by aggregated amyloid beta peptides (25-35) in mice and attenuated the amyloid beta (25-35)-induced accumulation of malondialdehyde and depletion of glutathione in the hippocampus.
Formal Description
Interaction-ID: 25424

drug/chemical compound

Silibinin

affects_quantity of

drug/chemical compound

Glutathione

in hippocampus
Drugbank entries Show/Hide entries for