General Information:

Id: 273
Diseases: Alzheimer disease - [OMIM]
Mus musculus
amyloid precursor protein transgenic mouse
brain
article
Reference: Kang JE et al.(2009) Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science 326: 1005-1007 [PMID: 19779148]

Interaction Information:

Comment Amyloid-beta (Abeta) accumulation in the brain extracellular space is a hallmark of Alzheimer disease.
Formal Description
Interaction-ID: 1111

increases_quantity of

gene/protein

Amyloid beta peptide

in brain extracellular space
Comment The amount of brain interstitial fluid levels (ISF) of Amyloid-beta is correlated with wakefulness.
Formal Description
Interaction-ID: 1112

affects_quantity of

gene/protein

Amyloid beta peptide

in brain interstitial fluid
Comment The amount of interstitial fluid levels of Amyloid-beta is significantly increased during orexin infusion.
Formal Description
Interaction-ID: 1119

gene/protein

HCRT

increases_quantity of

gene/protein

Amyloid beta peptide

in brain interstitial fluid
Drugbank entries Show/Hide entries for HCRT
Comment Chronic sleep restriction significantly increased, and a dual orexin receptor antagonist decreased, Amyloid-beta plaque formation in amyloid precursor protein transgenic mice.
Formal Description
Interaction-ID: 12966

environment

sleep restriction

increases_quantity of