General Information:

Id: 2,696 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
Reference: Emanuelli B et al.(2008) Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance. Proc. Natl. Acad. Sci. U.S.A. 105: 3545-3550 [PMID: 18296638]

Interaction Information:

Comment MKP-4 also reversed the effect of TNF-alpha to inhibit insulin signaling, to alter IL-6, Glut1 and Glut4 expression, and to inhibit insulin-stimulated glucose uptake in 3T3-L1 adipocytes.
Formal Description
Interaction-ID: 25228



decreases_activity of


glucose import

in adipose tissue
Drugbank entries Show/Hide entries for TNF