General Information:

Id: 268 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell
article
Reference: Ko HS et al.(2009) CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity. Proc. Natl. Acad. Sci. U.S.A. 106: 2897-2902 [PMID: 19196961]

Interaction Information:

Comment In contrast to LRRK2-WT, the R1441C and G2019S mutants of LRRK2 cause significant cell toxicity.
Formal Description
Interaction-ID: 1099

gene/protein mutant

LRRK2-p.R1441C

increases_activity of

process

neuron death

Comment In contrast to LRRK2-WT, the R1441C and G2019S mutants of LRRK2 cause significant cell toxicity.
Formal Description
Interaction-ID: 1100

gene/protein mutant

LRRK2-p.G2019S

increases_activity of

process

neuron death

Comment CHIP reduces LRRK2-R1441C and LRRK2-G2019S induced cell toxicity. This indicates that CHIP influences LRRK2 toxicity by regulating LRRK2 protein levels.
Formal Description
Interaction-ID: 1102

gene/protein

STUB1

decreases_activity of

process

neuron death

incuced by LRRK2 mutants
Comment Treatment with 17AAG, a HSP90 inhibitor, significantly protected against G2019S- and R1441C-LRRK2 mutant-induced cell death.
Formal Description
Interaction-ID: 3751

drug/chemical compound

17AAD

decreases_activity of

process

neuron death

induced by LRRK2 mutants