General Information:

Id: 2,689
Diseases: Endocrine
Postpartum depression
Mus musculus
BTO:0000007 HEK-293 cell
article
Reference: Schreiber SN et al.(2003) The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha). J. Biol. Chem. 278: 9013-9018 [PMID: 12522104]

Interaction Information:

Comment PGC-1 interacts physically with ERRalpha and enables it to activate transcription (potentially associated with postpartum depression).
Formal Description
Interaction-ID: 25170

gene/protein

PPARGC1A

interacts (colocalizes) with

gene/protein

ESRRA

Drugbank entries Show/Hide entries for ESRRA
Comment PGC-1 interacts physically with ERRalpha and enables it to activate transcription. PGC-1 converts ERRalpha from a factor with little or no transcriptional activity to a potent regulator of gene expression (potentially associated with postpartum depression).
Formal Description
Interaction-ID: 25171

gene/protein

PPARGC1A

increases_activity of

gene/protein

ESRRA

Drugbank entries Show/Hide entries for ESRRA