General Information:

Id: 2,651
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
G6pc2 (-/-) mouse
article
Reference: Wang Y et al.(2007) Deletion of the gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen results in a mild metabolic phenotype Diabetologia 50: 774-778 [PMID: 17265032]

Interaction Information:

Comment The size and number of islets in G6pc2 knockout animals were indistinguishable from wild-type as were the relative numbers of alpha and beta cells.
Formal Description
Interaction-ID: 25024

gene/protein

G6PC2

NOT affects_quantity of

tissue/cell line

pancreatic islet

Comment The size and number of islets in G6pc2 knockout animals were indistinguishable from wild-type as were the relative numbers of alpha and beta cells.
Formal Description
Interaction-ID: 25025

gene/protein

G6PC2

NOT affects_quantity of

tissue/cell line

pancreatic beta cell

Comment The size and number of islets in G6pc2 knockout animals were indistinguishable from wild-type as were the relative numbers of alpha and beta cells.
Formal Description
Interaction-ID: 25026

gene/protein

G6PC2

NOT affects_quantity of

tissue/cell line

pancreatic alpha cell

Comment In both male and female G6pc2-/- mice there was a statistically significant 14 and 11% decrease, respectively, in blood glucose in comparison with wild-type mice. The blood glucose level in male G6pc2-/- mice was also lower than that in male G6pc2-/+ mice.
Formal Description
Interaction-ID: 25027

gene/protein

G6PC2

affects_quantity of

drug/chemical compound

Glucose

in blood
Comment In female G6pc2-/- mice there was also a statistically significant 12% decrease in plasma triacylglycerol.
Formal Description
Interaction-ID: 25028

gene/protein

G6PC2

affects_quantity of

drug/chemical compound

Triacylglycerol

in blood plasma; in female mice
Comment There were no statistically significant differences in plasma cholesterol, glycerol, insulin and glucagon concentrations between G6pc2-/- and wild-type mice. G6pc2-/- mice showed sex-related variation in the majority of these metabolic parameters that were in the same direction and of similar magnitude to the sex-related differences in wild-type mice.
Formal Description
Interaction-ID: 25030

gene/protein

G6PC2

NOT affects_quantity of

drug/chemical compound

Cholesterol

in blood plasma
Drugbank entries Show/Hide entries for
Comment There were no statistically significant differences in plasma cholesterol, glycerol, insulin and glucagon concentrations between G6pc2-/- and wild-type mice. G6pc2-/- mice showed sex-related variation in the majority of these metabolic parameters that were in the same direction and of similar magnitude to the sex-related differences in wild-type mice.
Formal Description
Interaction-ID: 25031

gene/protein

G6PC2

NOT affects_quantity of

drug/chemical compound

Glycerol

in blood plasma
Drugbank entries Show/Hide entries for
Comment There were no statistically significant differences in plasma cholesterol, glycerol, insulin and glucagon concentrations between G6pc2-/- and wild-type mice. G6pc2-/- mice showed sex-related variation in the majority of these metabolic parameters that were in the same direction and of similar magnitude to the sex-related differences in wild-type mice.
Formal Description
Interaction-ID: 25033

gene/protein

G6PC2

NOT affects_quantity of

complex/PPI

Insulin

in blood plasma
Comment There were no statistically significant differences in plasma cholesterol, glycerol, insulin and glucagon concentrations between G6pc2-/- and wild-type mice. G6pc2-/- mice showed sex-related variation in the majority of these metabolic parameters that were in the same direction and of similar magnitude to the sex-related differences in wild-type mice.
Formal Description
Interaction-ID: 25034

gene/protein

G6PC2

NOT affects_quantity of

gene/protein

Glucagon

in blood plasma
Comment The data show no difference in insulin secretion between wild-type and G6pc2-/- mice. This suggests that the absence of G6PC2 affects fasting but not maximal glucose-stimulated insulin secretion, and is consistent with the conclusion that the absence of G6PC2 results in a mild metabolic phenotype.
Formal Description
Interaction-ID: 25036

gene/protein

G6PC2

NOT affects_activity of

in pancreas, in pancreatic beta cells
Comment In both male and female G6pc2-/- mice there was a statistically significant 14 and 11% decrease, respectively, in blood glucose in comparison with wild-type mice. The blood glucose level in male G6pc2-/- mice was also lower than that in male G6pc2-/+ mice.
Formal Description
Interaction-ID: 25653

gene/protein

G6PC2

affects_activity of