General Information:

Id: 261 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
BTO:0003694 CNS cell line; BTO:0004488 NSC-34 cell
article
Reference: Kanekura K et al.(2006) Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8) J. Biol. Chem. 281 [PMID: 16891305]

Interaction Information:

Comment Overexpression of wt-VAPB, but not that of P56S-VAPB, triggered UPR (unfolded protein response). No other P56X-VAPB derivatives (P56S, P56A, P56K, and P56D) nor P56del-VAPB (in which proline at position 56 is deleted) triggered UPR.
Formal Description
Interaction-ID: 1071

gene/protein

VAPB

increases_activity of

if VAPB is overexpressed
Comment Overexpression of wt-VAPB, but not that of P56S-VAPB, triggered UPR (unfolded protein response). No other P56X-VAPB derivatives (P56S, P56A, P56K, and P56D) nor P56del-VAPB (in which proline at position 56 is deleted) triggered UPR.
Formal Description
Interaction-ID: 1073

gene/protein mutant

VAPB-p.P56S

NOT increases_activity of

if P56S-VAPB is overexpressed
Comment Overexpression of wt-VAPA, but not that of P56S-VAPA, triggered UPR (unfolded protein response).
Formal Description
Interaction-ID: 1074

gene/protein

VAPA

increases_activity of

if VAPA is overexpressed
Comment Overexpression of wt-VAPA, but not that of P56S-VAPA, triggered UPR (unfolded protein response).
Formal Description
Interaction-ID: 1075

gene/protein mutant

VAPA-p.P56S

NOT increases_activity of

if P56S-VAPA is overexpressed
Comment Overexpression of VAMP1 or VAMP2, were unable to induce UPR (unfolded protein response).
Formal Description
Interaction-ID: 1076

gene/protein

VAMP1

NOT increases_activity of

if VAMP1 is overexpressed
Drugbank entries Show/Hide entries for VAMP1
Comment Overexpression of VAMP1 or VAMP2, were unable to induce UPR (unfolded protein response).
Formal Description
Interaction-ID: 1077

gene/protein

VAMP2

NOT increases_activity of

if VAMP2 is overexpressed
Drugbank entries Show/Hide entries for VAMP2