General Information:

Id: 2,596 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
primary cortical neurons
Reference: Berman DE et al.(2008) Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism Nat. Neurosci. 11: 547-554 [PMID: 18391946]

Interaction Information:

Comment Incubation of primary cortical neurons with oligomeric Abeta decreases the level of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2), a phospholipid that regulates key aspects of neuronal function. The destabilizing effect of Abeta on PtdIns(4,5)P2 metabolism was Ca2+-dependent.
Formal Description
Interaction-ID: 24526

drug/chemical compound


affects_activity of


Phosphatidylinositol-4,5-bisphosphate 5-phosphatase