General Information:

Id: 2,593
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
HEK293 cell
article
Reference: Mitterreiter S et al.(2010) Bepridil and amiodarone simultaneously target the Alzheimers disease beta- and gamma-secretase via distinct mechanisms. J. Neurosci. 30: 8974-8983 [PMID: 20592218]

Interaction Information:

Comment The two drugs, bepridil and amiodarone, are weak bases and in clinical use as calcium antagonists.
Formal Description
Interaction-ID: 24463

drug/chemical compound

Bepridil

decreases_activity of

drug/chemical compound

Ca2+

Drugbank entries Show/Hide entries for Bepridil
Comment The two drugs, bepridil and amiodarone, are weak bases and in clinical use as calcium antagonists.
Formal Description
Interaction-ID: 24464

drug/chemical compound

Amiodarone

decreases_activity of

drug/chemical compound

Ca2+

Drugbank entries Show/Hide entries for Amiodarone
Comment Bepridil and amiodarone mildly raised the membrane-proximal, endosomal pH and inhibited beta-secretase cleavage at therapeutically achievable concentrations in cultured cells, in primary neurons, and in vivo in guinea pigs.
Formal Description
Interaction-ID: 24465

drug/chemical compound

Bepridil

decreases_activity of

gene/protein

BACE1

Drugbank entries Show/Hide entries for Bepridil or BACE1
Comment Bepridil and amiodarone mildly raised the membrane-proximal, endosomal pH and inhibited beta-secretase cleavage at therapeutically achievable concentrations in cultured cells, in primary neurons, and in vivo in guinea pigs.
Formal Description
Interaction-ID: 24466

drug/chemical compound

Amiodarone

decreases_activity of

gene/protein

BACE1

Drugbank entries Show/Hide entries for Amiodarone or BACE1
Comment Bepridil and amiodarone mildly raised the membrane-proximal, endosomal pH and inhibited beta-secretase cleavage at therapeutically achievable concentrations in cultured cells, in primary neurons, and in vivo in guinea pigs.
Formal Description
Interaction-ID: 24467

drug/chemical compound

Bepridil

increases_activity of

Drugbank entries Show/Hide entries for Bepridil
Comment Bepridil and amiodarone mildly raised the membrane-proximal, endosomal pH and inhibited beta-secretase cleavage at therapeutically achievable concentrations in cultured cells, in primary neurons, and in vivo in guinea pigs.
Formal Description
Interaction-ID: 24468

drug/chemical compound

Amiodarone

increases_activity of

Drugbank entries Show/Hide entries for Amiodarone
Comment beta-Secretase has an acidic pH optimum and cleaves the amyloid precursor protein in the acidic endosomes.
Formal Description
Interaction-ID: 24472

decreases_activity of

gene/protein

BACE1

Drugbank entries Show/Hide entries for BACE1
Comment beta-Secretase has an acidic pH optimum and cleaves the amyloid precursor protein in the acidic endosomes.
Formal Description
Interaction-ID: 24473

gene/protein

BACE1

increases_processing of

gene/protein

APP

in the acidic endosomes
Drugbank entries Show/Hide entries for BACE1 or APP
Comment Bepridil and amiodarone also modulated gamma-secretase cleavage independently of endosomal alkalinization.
Formal Description
Interaction-ID: 24477

drug/chemical compound

Bepridil

affects_activity of

Drugbank entries Show/Hide entries for Bepridil
Comment Bepridil and amiodarone also modulated gamma-secretase cleavage independently of endosomal alkalinization.
Formal Description
Interaction-ID: 24478

drug/chemical compound

Amiodarone

affects_activity of

independently of endosomal alkalinization
Drugbank entries Show/Hide entries for Amiodarone
Comment beta-Secretase has an acidic pH optimum and cleaves the amyloid precursor protein in the acidic endosomes.
Formal Description
Interaction-ID: 82428

increases_activity of

gene/protein

BACE1

in the acidic endosomes
Drugbank entries Show/Hide entries for BACE1
Comment beta-Secretase has an acidic pH optimum and cleaves the amyloid precursor protein in the acidic endosomes.
Formal Description
Interaction-ID: 82429

gene/protein

BACE1

decreases_quantity of

gene/protein

APP

in the acidic endosomes; via cleaving APP
Drugbank entries Show/Hide entries for BACE1 or APP