General Information:

Id: 2,587 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Rattus norvegicus
article
Reference: Shimmyo Y et al.(2008) Multifunction of myricetin on A beta: neuroprotection via a conformational change of A beta and reduction of A beta via the interference of secretases. J. Neurosci. Res. 86: 368-377 [PMID: 17722071]

Interaction Information:

Comment Administration of myricetin significantly decreased Abeta (1-40) and Abeta (1-42) levels in culture media. These effects were based on two mechanisms: the activation and up-regulation of alpha-secretase (ADAM10) protein levels as indicated by fluorescence resonance energy transfer (FRET) assay and immunoblot analysis and the direct binding and inhibition of beta-secretase (BACE-1) indicated by cell-free FRET assays.
Formal Description
Interaction-ID: 24429

drug/chemical compound

Myricetin

increases_activity of

gene/protein

ADAM10

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