General Information:

Id: 2,587 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Rattus norvegicus
article
Reference: Shimmyo Y et al.(2008) Multifunction of myricetin on A beta: neuroprotection via a conformational change of A beta and reduction of A beta via the interference of secretases. J. Neurosci. Res. 86: 368-377 [PMID: 17722071]

Interaction Information:

Comment Myricetin (3,3',4',5,5',7-hexahydroxyflavone) is classified as a flavonoid with strong antioxidant effects.
Formal Description
Interaction-ID: 24411

drug/chemical compound

Myricetin

increases_activity of

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Comment Pre- and simultaneous administration of myricetin and Abeta (1-42) reduced Abeta neurotoxicity in a concentration-dependent manner. Myricetin prevented structural changes in Abeta (1-42) from a random coil to a beta-sheet-rich structure.
Formal Description
Interaction-ID: 24413

drug/chemical compound

Myricetin

decreases_activity of

process

neuron death

caused by Abeta neurotoxicity
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Comment Abeta (1-42)-induced apoptotic changes and caspase-3 activation were reduced by myricetin treatment.
Formal Description
Interaction-ID: 24414

drug/chemical compound

Myricetin

decreases_activity of

phenotype

amyloidosis

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Comment Abeta (1-42)-induced apoptotic changes and caspase-3 activation were reduced by myricetin treatment.
Formal Description
Interaction-ID: 24415

drug/chemical compound

Myricetin

decreases_activity of

gene/protein

CASP3

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Comment Administration of myricetin significantly decreased Abeta (1-40) and Abeta (1-42) levels in culture media.
Formal Description
Interaction-ID: 24416

drug/chemical compound

Myricetin

decreases_quantity of

Drugbank entries Show/Hide entries for Myricetin
Comment Administration of myricetin significantly decreased Abeta (1-40) and Abeta (1-42) levels in culture media.
Formal Description
Interaction-ID: 24417

drug/chemical compound

Myricetin

decreases_quantity of

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Comment Administration of myricetin significantly decreased Abeta (1-40) and Abeta (1-42) levels in culture media. These effects were based on two mechanisms: the activation and up-regulation of alpha-secretase (ADAM10) protein levels as indicated by fluorescence resonance energy transfer (FRET) assay and immunoblot analysis and the direct binding and inhibition of beta-secretase (BACE-1) indicated by cell-free FRET assays.
Formal Description
Interaction-ID: 24429

drug/chemical compound

Myricetin

increases_activity of

gene/protein

ADAM10

Drugbank entries Show/Hide entries for Myricetin
Comment Administration of myricetin significantly decreased Abeta (1-40) and Abeta (1-42) levels in culture media. These effects were based on two mechanisms: the activation and up-regulation of alpha-secretase (ADAM10) protein levels as indicated by fluorescence resonance energy transfer (FRET) assay and immunoblot analysis and the direct binding and inhibition of beta-secretase (BACE-1) indicated by cell-free FRET assays.
Formal Description
Interaction-ID: 24430

drug/chemical compound

Myricetin

increases_expression of

gene/protein

ADAM10

Drugbank entries Show/Hide entries for Myricetin
Comment Administration of myricetin significantly decreased Abeta (1-40) and Abeta (1-42) levels in culture media. These effects were based on two mechanisms: the activation and up-regulation of alpha-secretase (ADAM10) protein levels as indicated by fluorescence resonance energy transfer (FRET) assay and immunoblot analysis and the direct binding and inhibition of beta-secretase (BACE-1) indicated by cell-free FRET assays.
Formal Description
Interaction-ID: 24431

drug/chemical compound

Myricetin

decreases_activity of

gene/protein

BACE1

by direct binding and inhibition
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Comment Administration of myricetin significantly decreased Abeta (1-40) and Abeta (1-42) levels in culture media. These effects were based on two mechanisms: the activation and up-regulation of alpha-secretase (ADAM10) protein levels as indicated by fluorescence resonance energy transfer (FRET) assay and immunoblot analysis and the direct binding and inhibition of beta-secretase (BACE-1) indicated by cell-free FRET assays.
Formal Description
Interaction-ID: 82427

drug/chemical compound

Myricetin

interacts (colocalizes) with

gene/protein

BACE1

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