General Information:

Id: 2,584
Diseases: Alzheimer disease - [OMIM]
Rattus norvegicus
BTO:0001009 PC-12 cells
article
Reference: Casas-Tinto S et al.(2011) The ER stress factor XBP1s prevents amyloid-beta neurotoxicity. Hum. Mol. Genet. 20: 2144-2160 [PMID: 21389082]

Interaction Information:

Comment Mechanisms mediating XBP1s neuroprotection: PC12 cells treated with Abeta oligomers, XBP1s prevents the accumulation of free calcium (Ca2+) in the cytosol.
Formal Description
Interaction-ID: 24343

gene/protein

XBP1

decreases_quantity of

drug/chemical compound

Ca2+

in PC12 cells treated with Abeta oligomers
Comment The protective activity of XBP1 can be mediated by the downregulation of a specific isoform of the ryanodine Ca2+ channel, RyR3.
Formal Description
Interaction-ID: 24344

gene/protein

RYR3

affects_activity of

gene/protein

XBP1