CIDeRGeneral Information:
| Id: | 2,580 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Homo sapiens | |
| article | |
| Reference: | Florez JC et al.(2007) Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program Diabetes 56: 531-536 [PMID: 17259403] |
Interaction Information:
| Comment | As previously shown in other studies, lysine carriers at KCNJ11 E23K had reduced insulin secretion at baseline; however, they were less likely to develop diabetes than E/E homozygotes. Lysine carriers were less protected by 1-year metformin treatment than E/E homozygotes. Results for ABCC8 A1369S were essentially identical to those for KCNJ11 E23K. |
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Formal Description Interaction-ID: 24318 |
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