General Information:

Id: 2,578 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Lang V et al.(2011) The molecular genetics of sulfonylurea receptors in the pathogenesis and treatment of insulin secretory disorders and type 2 diabetes Curr. Diab. Rep. 11: 543-551 [PMID: 21968738]

Interaction Information:

Comment Increases in plasma glucose levels lead to elevations in beta-cell glucose metabolism and closure of basally active K(ATP) channels, resulting in membrane depolarization. The subsequent opening of voltage-gated calcium channels results in calcium entry and calcium-triggered exocytosis of insulin-containing granules.
Formal Description
Interaction-ID: 24275

drug/chemical compound

Ca2+

increases_activity of

in pancreas, in pancreatic beta cells