General Information:

Id: 2,578 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Lang V et al.(2011) The molecular genetics of sulfonylurea receptors in the pathogenesis and treatment of insulin secretory disorders and type 2 diabetes Curr. Diab. Rep. 11: 543-551 [PMID: 21968738]

Interaction Information:

Comment The ATP-sensitive potassium channel complex (K(ATP) channel) expressed in pancreatic alpha- and beta-cells, glucagon-like peptide-1-secreting intestinal L-cells, and neurons is composed of the beta-cell high-affinity sulfonylurea receptor (SUR1) and the inward rectifier potassium channel (Kir6.2) subunits encoded by the ABCC8 and KCNJ11 genes, respectively.
Formal Description
Interaction-ID: 24268

gene/protein

ABCC8

is_part_of

complex/PPI

ATP-sensitive potassium channel complex

in pancreas, in pancratic beta cells, in pancreatic alpha cells, in intestinal L-cells, in neurons
Drugbank entries Show/Hide entries for ABCC8
Comment The ATP-sensitive potassium channel complex (K(ATP) channel) expressed in pancreatic alpha- and beta-cells, glucagon-like peptide-1-secreting intestinal L-cells, and neurons is composed of the beta-cell high-affinity sulfonylurea receptor (SUR1) and the inward rectifier potassium channel (Kir6.2) subunits encoded by the ABCC8 and KCNJ11 genes, respectively.
Formal Description
Interaction-ID: 24269

gene/protein

KCNJ11

is_part_of

complex/PPI

ATP-sensitive potassium channel complex

in pancreas, in pancratic beta cells, in pancreatic alpha cells, in intestinal L-cells, in neurons
Drugbank entries Show/Hide entries for KCNJ11
Comment In pancreatic beta cells, K(ATP) channels play a vital role by acting as intracellular sensors of glucose metabolism, thus controlling insulin secretion.
Formal Description
Interaction-ID: 24270

complex/PPI

ATP-sensitive potassium channel complex

affects_activity of

in pancreas, in pancreatic beta cells
Comment Genetic mutations in the KCNJ11 and ABCC8 genes have been linked to persistent hyperinsulinemic hypoglycemia of infancy (PHHI) and neonatal diabetes (ND).
Formal Description
Interaction-ID: 24300

gene/protein

ABCC8

affects_activity of

Drugbank entries Show/Hide entries for ABCC8
Comment In direct contrast to rare monogenic mutations that result in overt insulin secretory disorders, common genetic variants in the KCNJ11 and ABCC8 genes may not manifest a clinical phenotype but are associated with an increased risk for diabetes. For example, the K23 single nucleotide variant (E23K, rs5219) within the KCNJ11 gene is associated with impaired glucose-stimulated insulin secretion in approximately 20% of the Caucasian T2D population. Moreover, the K23 variant has also been shown to be associated with T2D in almost every ethnic group examined. The ABCC8 A1369 variant (rs757110) is tightly associated with the K23 variant, forming a T2D risk haplotype (K/A), such that greater than 95% of people with two copies of K23 also possess two copies of A1369. It should also be noted that the ABCC8 and KCNJ11 genes are located adjacent to each other on the same chromosomal position (11p15.1), further supporting a tight inheritable risk haplotype that may alter the properties of the K(ATP) channel complex.
Formal Description
Interaction-ID: 24312

increases_activity of

the risk allele is G