General Information:

Id: 2,578 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Lang V et al.(2011) The molecular genetics of sulfonylurea receptors in the pathogenesis and treatment of insulin secretory disorders and type 2 diabetes Curr. Diab. Rep. 11: 543-551 [PMID: 21968738]

Interaction Information:

Comment The ATP-sensitive potassium channel complex (K(ATP) channel) expressed in pancreatic alpha- and beta-cells, glucagon-like peptide-1-secreting intestinal L-cells, and neurons is composed of the beta-cell high-affinity sulfonylurea receptor (SUR1) and the inward rectifier potassium channel (Kir6.2) subunits encoded by the ABCC8 and KCNJ11 genes, respectively.
Formal Description
Interaction-ID: 24268

gene/protein

ABCC8

is_part_of

complex/PPI

ATP-sensitive potassium channel complex

in pancreas, in pancratic beta cells, in pancreatic alpha cells, in intestinal L-cells, in neurons
Drugbank entries Show/Hide entries for ABCC8