General Information:

Id: 2,539
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Ling C et al.(2008) Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion Diabetologia 51: 615-622 [PMID: 18270681]

Interaction Information:

Comment PPARGC1A mRNA expression was reduced by 90% and correlated with the reduction in insulin secretion in islets from patients with type 2 diabetes.
Formal Description
Interaction-ID: 23640

decreases_expression of

gene/protein

PPARGC1A

Comment PPARGC1A mRNA expression was reduced by 90% and correlated with the reduction in insulin secretion in islets from patients with type 2 diabetes.
Formal Description
Interaction-ID: 23641

gene/protein

PPARGC1A

affects_activity of

Comment Reduced PPARGC1A expression in islets can be ascribed to both genetic and epigenetic factors, i.e. a common PPARGC1A Gly482Ser polymorphism was associated with reduced PPARGC1A mRNA expression and reduced insulin secretion. In support of an epigenetic influence, the PPARGC1A gene promoter showed a twofold increase in DNA methylation in diabetic islets compared with non-diabetic islets.
Formal Description
Interaction-ID: 23642

decreases_expression of

gene/protein

PPARGC1A

Comment Reduced PPARGC1A expression in islets can be ascribed to both genetic and epigenetic factors, i.e. a common PPARGC1A Gly482Ser polymorphism was associated with reduced PPARGC1A mRNA expression and reduced insulin secretion. In support of an epigenetic influence, the PPARGC1A gene promoter showed a twofold increase in DNA methylation in diabetic islets compared with non-diabetic islets.
Formal Description
Interaction-ID: 23643

decreases_activity of

Comment Reduced PPARGC1A expression in islets can be ascribed to both genetic and epigenetic factors, i.e. a common PPARGC1A Gly482Ser polymorphism was associated with reduced PPARGC1A mRNA expression and reduced insulin secretion. In support of an epigenetic influence, the PPARGC1A gene promoter showed a twofold increase in DNA methylation in diabetic islets compared with non-diabetic islets.
Formal Description
Interaction-ID: 23644

decreases_expression of

gene/protein

PPARGC1A

in pancreas, in pancreatic islets; via increased promoter DNA methylation