General Information:

Id: 2,533 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Di Paolo G and Kim TW(2011) Linking lipids to Alzheimers disease: cholesterol and beyond. Nat. Rev. Neurosci. 12: 284-296 [PMID: 21448224]

Interaction Information:

Comment Acute cell exposure to cholesterol promotes the co-clustering of APP and BACE1 in lipid raft domains, as well as their rapid endocytosis.
Formal Description
Interaction-ID: 24085

drug/chemical compound

Cholesterol

affects_activity of

process

endocytosis

of APP and BACE1
Drugbank entries Show/Hide entries for Cholesterol