General Information:

Id: 2,533 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Di Paolo G and Kim TW(2011) Linking lipids to Alzheimers disease: cholesterol and beyond. Nat. Rev. Neurosci. 12: 284-296 [PMID: 21448224]

Interaction Information:

Comment Reducing membrane cholesterol levels through cholesterol-extracting compounds, such as beta-methyl cyclodextrin (betaMCD), decreases activity of both BACE1 and gamma-secretase, leading to an additive reduction in amyloid-beta generation.
Formal Description
Interaction-ID: 23827

drug/chemical compound

Cholesterol

affects_quantity of

gene/protein

Amyloid beta peptide

Drugbank entries Show/Hide entries for Cholesterol