General Information:

Id: 2,532 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Le Bacquer O et al.(2011) TCF7L2 splice variants have distinct effects on beta-cell turnover and function. Hum. Mol. Genet. 20: 1906-1915 [PMID: 21357677]

Interaction Information:

Comment The study identified TCF7L2 transcripts in the human beta-cell, which had opposite effects on beta-cell survival, function and Wnt signaling activation. While TCF7L2 clone B1, which lacks exons 13, 14, 15 and 16 induced beta-cell apoptosis, impaired function and inhibited glucagon-like peptide 1 response and downstream targets of Wnt signaling, clones B3 and B7 which both contain exon 13, improved beta-cell survival and function and activated Wnt signaling.
Formal Description
Interaction-ID: 23587

mRNA/protein variant

TCF7L2 variant B7

increases_activity of

process

canonical Wnt signaling pathway

in pancreas, in pancreatic islets