General Information:

Id: 2,530 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
3xTg-AD mouse = triple transgenic AD mouse model (3xTg-AD) with 2 familial AD-related gene mutations (APP(KM670/671NL) /PS1(M146V)) and a tau gene mutation (Tau(P301L))
article
Reference: Himeno E et al.(2011) Apomorphine treatment in Alzheimer mice promoting amyloid-beta degradation. Ann. Neurol. 69: 248-256 [PMID: 21387370]

Interaction Information:

Comment APO promoted degradation of intracellular Abeta, increased activity of proteasome and insulin-degrading enzyme, protected against H(2)O(2) toxicity, and decreased p53 protein levels in the cultured cells.
Formal Description
Interaction-ID: 23562

drug/chemical compound

Apomorphine

decreases_activity of

drug/chemical compound

H2O2

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