General Information:
Id: | 2,503 (click here to show other Interactions for entry) |
Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
Mus musculus | |
male | |
article | |
Reference: | El Muayed M et al.(2010) Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic beta-cell function. J. Endocrinol. 206: 159-169 [PMID: 20508080] |
Interaction Information:
Comment | ZnT8 knockdown in murine islets led to reduced glucose stimulated insulin secretion without altering the total cellular insulin content or cell viability at normal or supraphysiological Zn concentrations. The results suggest that an acute decrease in ZnT8 levels impairs beta-cell function and Zn homeostasis, and may contribute to inflammatory cytokine-induced alterations in beta-cell function. |
Formal Description Interaction-ID: 23323 |
gene/protein affects_activity of process |