General Information:

Id: 2,503
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: El Muayed M et al.(2010) Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic beta-cell function. J. Endocrinol. 206: 159-169 [PMID: 20508080]

Interaction Information:

Comment Exposure of MIN6 cells or primary murine islets to IL1 beta or TNFalpha altered the mRNA expression profile of Zn transporters; most notable was decreased ZnT8 mRNA levels.
Formal Description
Interaction-ID: 23310

gene/protein

IL1B

decreases_expression of

gene/protein

SLC39A1

in pancreas, in pancreatic beta cells
Drugbank entries Show/Hide entries for IL1B
Comment Exposure of MIN6 cells or primary murine islets to IL1 beta or TNFalpha altered the mRNA expression profile of Zn transporters; most notable was decreased ZnT8 mRNA levels.
Formal Description
Interaction-ID: 23311

gene/protein

TNF

decreases_expression of

gene/protein

SLC39A1

in pancreas, in pancreatic beta cells
Drugbank entries Show/Hide entries for TNF
Comment Exposure of MIN6 cells or primary murine islets to IL1 beta or TNFalpha altered the mRNA expression profile of Zn transporters; most notable was decreased ZnT8 mRNA levels.
Formal Description
Interaction-ID: 23312

gene/protein

IL1B

decreases_expression of

gene/protein

SLC39A13

in pancreas, in pancreatic beta cells
Drugbank entries Show/Hide entries for IL1B
Comment Exposure of MIN6 cells or primary murine islets to IL1 beta or TNFalpha altered the mRNA expression profile of Zn transporters; most notable was decreased ZnT8 mRNA levels.
Formal Description
Interaction-ID: 23313

gene/protein

IL1B

decreases_expression of

gene/protein

SLC39A14

in pancreas, in pancreatic beta cells
Drugbank entries Show/Hide entries for IL1B
Comment Exposure of MIN6 cells or primary murine islets to IL1 beta or TNFalpha altered the mRNA expression profile of Zn transporters; most notable was decreased ZnT8 mRNA levels.
Formal Description
Interaction-ID: 23314

gene/protein

IL1B

decreases_expression of

gene/protein

SLC39A4

in pancreas, in pancreatic beta cells
Drugbank entries Show/Hide entries for IL1B
Comment Exposure of MIN6 cells or primary murine islets to IL1 beta or TNFalpha altered the mRNA expression profile of Zn transporters; most notable was decreased ZnT8 mRNA levels.
Formal Description
Interaction-ID: 23315

gene/protein

TNF

decreases_expression of

gene/protein

SLC39A4

in pancreas, in pancreatic beta cells
Drugbank entries Show/Hide entries for TNF
Comment Exposure of MIN6 cells or primary murine islets to IL1 beta or TNFalpha altered the mRNA expression profile of Zn transporters; most notable was decreased ZnT8 mRNA levels.
Formal Description
Interaction-ID: 23317

gene/protein

TNF

decreases_expression of

gene/protein

SLC39A8

in pancreas, in pancreatic beta cells
Drugbank entries Show/Hide entries for TNF
Comment Exposure of MIN6 cells or primary murine islets to IL1 beta or TNFalpha altered the mRNA expression profile of Zn transporters; most notable was decreased ZnT8 mRNA levels.
Formal Description
Interaction-ID: 23318

gene/protein

TNF

decreases_expression of

gene/protein

SLC39A10

in pancreas, in pancreatic beta cells
Drugbank entries Show/Hide entries for TNF
Comment Exposure of MIN6 cells or primary murine islets to IL1 beta or TNFalpha altered the mRNA expression profile of Zn transporters; most notable was decreased ZnT8 mRNA levels.
Formal Description
Interaction-ID: 23319

gene/protein

TNF

decreases_expression of

gene/protein

SLC30A5

in pancreas, in pancreatic beta cells
Drugbank entries Show/Hide entries for TNF
Comment Exposure of MIN6 cells or primary murine islets to IL1 beta or TNFalpha altered the mRNA expression profile of Zn transporters; most notable was decreased ZnT8 mRNA levels.
Formal Description
Interaction-ID: 23320

gene/protein

IL1B

decreases_expression of

gene/protein

SLC30A5

in pancreas, in pancreatic beta cells
Drugbank entries Show/Hide entries for IL1B
Comment Exposure of MIN6 cells or primary murine islets to IL1 beta or TNFalpha altered the mRNA expression profile of Zn transporters; most notable was decreased ZnT8 mRNA levels.
Formal Description
Interaction-ID: 23321

gene/protein

IL1B

decreases_expression of

gene/protein

SLC30A8

in pancreas, in pancreatic beta cells
Drugbank entries Show/Hide entries for IL1B
Comment Exposure of MIN6 cells or primary murine islets to IL1 beta or TNFalpha altered the mRNA expression profile of Zn transporters; most notable was decreased ZnT8 mRNA levels.
Formal Description
Interaction-ID: 23322

gene/protein

TNF

decreases_expression of

gene/protein

SLC30A8

in pancreas, in pancreatic beta cells
Drugbank entries Show/Hide entries for TNF
Comment ZnT8 knockdown in murine islets led to reduced glucose stimulated insulin secretion without altering the total cellular insulin content or cell viability at normal or supraphysiological Zn concentrations. The results suggest that an acute decrease in ZnT8 levels impairs beta-cell function and Zn homeostasis, and may contribute to inflammatory cytokine-induced alterations in beta-cell function.
Formal Description
Interaction-ID: 23323

gene/protein

SLC30A8

affects_activity of

in pancreas, in pancreatic beta cells