General Information:

Id: 2,493
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Ingelsson E et al.(2010) Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans Diabetes 59: 1266-1275 [PMID: 20185807]

Interaction Information:

Comment The glucose-raising allele in MADD was associated with abnormal insulin processing (a dramatic effect on higher proinsulin levels, but no association with insulinogenic index) at extremely persuasive levels of statistical significance.
Formal Description
Interaction-ID: 23232

affects_activity of

the effective allele is A
Comment Defects in insulin processing and insulin secretion were seen in glucose-raising allele carriers at TCF7L2, SCL30A8, GIPR, and C2CD4B.
Formal Description
Interaction-ID: 23233

affects_activity of

the effective allele is T
Comment Defects in insulin processing and insulin secretion were seen in glucose-raising allele carriers at TCF7L2, SCL30A8, GIPR, and C2CD4B.
Formal Description
Interaction-ID: 23234

affects_activity of

the effective allele is C
Comment Defects in insulin processing and insulin secretion were seen in glucose-raising allele carriers at TCF7L2, SCL30A8, GIPR, and C2CD4B.
Formal Description
Interaction-ID: 23235

affects_activity of

the effective allele is A
Comment Defects in insulin processing and insulin secretion were seen in glucose-raising allele carriers at TCF7L2, SCL30A8, GIPR, and C2CD4B.
Formal Description
Interaction-ID: 23236

affects_activity of

the effective allele is A
Comment Defects in insulin processing and insulin secretion were seen in glucose-raising allele carriers at TCF7L2, SCL30A8, GIPR, and C2CD4B.
Formal Description
Interaction-ID: 23237

affects_activity of

the effective allele is T
Comment Defects in insulin processing and insulin secretion were seen in glucose-raising allele carriers at TCF7L2, SCL30A8, GIPR, and C2CD4B.
Formal Description
Interaction-ID: 23238

affects_activity of

the effective allele is C
Comment Defects in insulin processing and insulin secretion were seen in glucose-raising allele carriers at TCF7L2, SCL30A8, GIPR, and C2CD4B.
Formal Description
Interaction-ID: 23239

affects_activity of

the effective allele is A
Comment Defects in insulin processing and insulin secretion were seen in glucose-raising allele carriers at TCF7L2, SCL30A8, GIPR, and C2CD4B.
Formal Description
Interaction-ID: 23240

affects_activity of

the effective allele is A
Comment Abnormalities in early insulin secretion were suggested in glucose-raising allele carriers at MTNR1B, GCK, FADS1, DGKB, and PROX1 (lower insulinogenic index; no association with proinsulin or insulin sensitivity).
Formal Description
Interaction-ID: 23241

affects_activity of

process

insulin secretion, first phase

the effective allele is G
Comment Abnormalities in early insulin secretion were suggested in glucose-raising allele carriers at MTNR1B, GCK, FADS1, DGKB, and PROX1 (lower insulinogenic index; no association with proinsulin or insulin sensitivity).
Formal Description
Interaction-ID: 23242

affects_activity of

process

insulin secretion, first phase

the effective allele is A
Comment Abnormalities in early insulin secretion were suggested in glucose-raising allele carriers at MTNR1B, GCK, FADS1, DGKB, and PROX1 (lower insulinogenic index; no association with proinsulin or insulin sensitivity).
Formal Description
Interaction-ID: 23243

affects_activity of

process

insulin secretion, first phase

the effective allele is T
Comment Abnormalities in early insulin secretion were suggested in glucose-raising allele carriers at MTNR1B, GCK, FADS1, DGKB, and PROX1 (lower insulinogenic index; no association with proinsulin or insulin sensitivity).
Formal Description
Interaction-ID: 23244

affects_activity of

process

insulin secretion, first phase

the effective allele is T
Comment Abnormalities in early insulin secretion were suggested in glucose-raising allele carriers at MTNR1B, GCK, FADS1, DGKB, and PROX1 (lower insulinogenic index; no association with proinsulin or insulin sensitivity).
Formal Description
Interaction-ID: 23245

affects_activity of

process

insulin secretion, first phase

the effective allele is C
Comment Two loci previously associated with fasting insulin (GCKR and IGF1) were associated with OGTT-derived insulin sensitivity indices in a consistent direction.
Formal Description
Interaction-ID: 23246

affects_activity of

the effective allele is C
Comment Two loci previously associated with fasting insulin (GCKR and IGF1) were associated with OGTT-derived insulin sensitivity indices in a consistent direction.
Formal Description
Interaction-ID: 23247

affects_activity of

the effective allele is G