General Information:

Id: 247 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Verdile G et al.(2007) The role of presenilin and its interacting proteins in the biogenesis of Alzheimers beta amyloid. Neurochem. Res. 32: 609-623 [PMID: 16944319]

Interaction Information:

Comment The biogenesis and accumulation of the beta amyloid protein (Abeta) is a key event in the cascade of oxidative and inflammatory processes that characterises Alzheimer's disease. The presenilins and its interacting proteins play a pivotal role in the generation of Abeta from the amyloid precursor protein (APP).
Formal Description
Interaction-ID: 1019

gene/protein

Amyloid beta peptide

affects_activity of