General Information:

Id: 2,469
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Saxena R et al.(2010) Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge Nat. Genet. 2: 142-148 [PMID: 20081857]

Interaction Information:

Comment A meta-analysis of nine genome-wide association studies identified variants at the GIPR locus associated with 2-h glucose level (rs10423928). The GIPR A-allele carriers also showed decreased insulin secretion and diminished incretin effect . The analysis also identified variants at ADCY5 (rs2877716), VPS13C (rs17271305), GCKR (rs1260326) and TCF7L2 (rs7903146) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies.
Formal Description
Interaction-ID: 22830

affects_activity of

phenotype

abnormal 2-h glucose level

the effective allele is A
Comment A meta-analysis of nine genome-wide association studies identified variants at the GIPR locus associated with 2-h glucose level (rs10423928). The GIPR A-allele carriers also showed decreased insulin secretion and diminished incretin effect . The analysis also identified variants at ADCY5 (rs2877716), VPS13C (rs17271305), GCKR (rs1260326) and TCF7L2 (rs7903146) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies.
Formal Description
Interaction-ID: 22831

decreases_activity of

in pancreas, in pancreatic islets; the effective allele is A
Comment A meta-analysis of nine genome-wide association studies identified variants at the GIPR locus associated with 2-h glucose level (rs10423928). The GIPR A-allele carriers also showed decreased insulin secretion and diminished incretin effect . The analysis also identified variants at ADCY5 (rs2877716), VPS13C (rs17271305), GCKR (rs1260326) and TCF7L2 (rs7903146) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies.
Formal Description
Interaction-ID: 22834

decreases_activity of

process

incretin effect

the effective allele is A
Comment A meta-analysis of nine genome-wide association studies identified variants at the GIPR locus associated with 2-h glucose level (rs10423928). The GIPR A-allele carriers also showed decreased insulin secretion and diminished incretin effect . The analysis also identified variants at ADCY5 (rs2877716), VPS13C (rs17271305), GCKR (rs1260326) and TCF7L2 (rs7903146) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies.
Formal Description
Interaction-ID: 22835

affects_activity of

phenotype

abnormal 2-h glucose level

the effective allele is C
Comment A meta-analysis of nine genome-wide association studies identified variants at the GIPR locus associated with 2-h glucose level (rs10423928). The GIPR A-allele carriers also showed decreased insulin secretion and diminished incretin effect . The analysis also identified variants at ADCY5 (rs2877716), VPS13C (rs17271305), GCKR (rs1260326) and TCF7L2 (rs7903146) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies.
Formal Description
Interaction-ID: 22836

affects_activity of

phenotype

abnormal 2-h glucose level

the effective allele is G
Comment A meta-analysis of nine genome-wide association studies identified variants at the GIPR locus associated with 2-h glucose level (rs10423928). The GIPR A-allele carriers also showed decreased insulin secretion and diminished incretin effect . The analysis also identified variants at ADCY5 (rs2877716), VPS13C (rs17271305), GCKR (rs1260326) and TCF7L2 (rs7903146) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies.
Formal Description
Interaction-ID: 22840

affects_activity of

phenotype

abnormal 2-h glucose level

Comment A meta-analysis of nine genome-wide association studies identified variants at the GIPR locus associated with 2-h glucose level (rs10423928). The GIPR A-allele carriers also showed decreased insulin secretion and diminished incretin effect . The analysis also identified variants at ADCY5 (rs2877716), VPS13C (rs17271305), GCKR (rs1260326) and TCF7L2 (rs7903146) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies.
Formal Description
Interaction-ID: 22848

affects_activity of

phenotype

abnormal 2-h glucose level

the effective allele is T
Comment A meta-analysis of nine genome-wide association studies identified variants at the GIPR locus associated with 2-h glucose level (rs10423928). The GIPR A-allele carriers also showed decreased insulin secretion and diminished incretin effect . The analysis also identified variants at ADCY5 (rs2877716), VPS13C (rs17271305), GCKR (rs1260326) and TCF7L2 (rs7903146) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies.
Formal Description
Interaction-ID: 22854

increases_activity of

the risk allele is C
Comment A meta-analysis of nine genome-wide association studies identified variants at the GIPR locus associated with 2-h glucose level (rs10423928). The GIPR A-allele carriers also showed decreased insulin secretion and diminished incretin effect . The analysis also identified variants at ADCY5 (rs2877716), VPS13C (rs17271305), GCKR (rs1260326) and TCF7L2 (rs7903146) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies.
Formal Description
Interaction-ID: 22858

NOT increases_activity of

Comment A meta-analysis of nine genome-wide association studies identified variants at the GIPR locus associated with 2-h glucose level (rs10423928). The GIPR A-allele carriers also showed decreased insulin secretion and diminished incretin effect . The analysis also identified variants at ADCY5 (rs2877716), VPS13C (rs17271305), GCKR (rs1260326) and TCF7L2 (rs7903146) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies.
Formal Description
Interaction-ID: 22861

NOT increases_activity of

Comment The study found 5 genome-wide significant loci for 2-h glucose during an OGTT from 26 studies in nondiabetic individuals.
Formal Description
Interaction-ID: 22929

affects_activity of

phenotype

abnormal 2-h glucose level

in nondiabetic individuals
Comment The study found 5 genome-wide significant loci for 2-h glucose during an OGTT from 26 studies in nondiabetic individuals.
Formal Description
Interaction-ID: 22932

affects_activity of

phenotype

abnormal 2-h glucose level

in nondiabetic individuals, the effective allele is C
Comment The study found 5 genome-wide significant loci for 2-h glucose during an OGTT from 26 studies in nondiabetic individuals.
Formal Description
Interaction-ID: 22933

affects_activity of

phenotype

abnormal 2-h glucose level

in nondiabetic individuals
Comment The study found 5 genome-wide significant loci for 2-h glucose during an OGTT from 26 studies in nondiabetic individuals.
Formal Description
Interaction-ID: 22934

affects_activity of

phenotype

abnormal 2-h glucose level

in nondiabetic individuals, the effective allele is G
Comment The study found 5 genome-wide significant loci for 2-h glucose during an OGTT from 26 studies in nondiabetic individuals.
Formal Description
Interaction-ID: 22935

affects_activity of

phenotype

abnormal 2-h glucose level

in nondiabetic individuals, the effective allele is A
Comment A meta-analysis of nine genome-wide association studies identified variants at the GIPR locus associated with 2-h glucose level (rs10423928). The GIPR A-allele carriers also showed decreased insulin secretion and diminished incretin effect . The analysis also identified variants at ADCY5 (rs2877716), VPS13C (rs17271305), GCKR (rs1260326) and TCF7L2 (rs7903146) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies.
Formal Description
Interaction-ID: 72842

gene/protein

GIPR

increases_activity of

in pancreas, in pancreatic islets; the effective allele is A