General Information:

Id: 2,467
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
Japanese, Koreans, Chinese, Europeans
article
Reference: Yasuda K et al.(2008) Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus Nat. Genet. 40: 1092-1097 [PMID: 18711367]

Interaction Information:

Comment In a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, ten SNPs were identified. The most significant association was obtained with SNPs in KCNQ1, rs2237892 in intron 15 showed the lowest Pvalue. The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations. Among control subjects, the risk allele of this polymorphism was associated with impairment of insulin secretion.
Formal Description
Interaction-ID: 22805

increases_activity of

in Japanese, the risk allele is C
Comment In a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, ten SNPs were identified. The most significant association was obtained with SNPs in KCNQ1, rs2237892 in intron 15 showed the lowest Pvalue. The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations. Among control subjects, the risk allele of this polymorphism was associated with impairment of insulin secretion.
Formal Description
Interaction-ID: 22806

increases_activity of

in Japanese, the risk allele is G
Comment In a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, ten SNPs were identified. The most significant association was obtained with SNPs in KCNQ1, rs2237892 in intron 15 showed the lowest Pvalue. The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations. Among control subjects, the risk allele of this polymorphism was associated with impairment of insulin secretion.
Formal Description
Interaction-ID: 22807

increases_activity of

in Japanese, in Koreans, in Chinese, in Europeans, the risk allele is C
Comment In a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, ten SNPs were identified. The most significant association was obtained with SNPs in KCNQ1, rs2237892 in intron 15 showed the lowest Pvalue. The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations. Among control subjects, the risk allele of this polymorphism was associated with impairment of insulin secretion.
Formal Description
Interaction-ID: 22808

increases_activity of

in Japanese, the risk allele is C
Comment In a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, ten SNPs were identified. The most significant association was obtained with SNPs in KCNQ1, rs2237892 in intron 15 showed the lowest Pvalue. The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations. Among control subjects, the risk allele of this polymorphism was associated with impairment of insulin secretion.
Formal Description
Interaction-ID: 22809

increases_activity of

in Japanese, the risk allele is C
Comment In a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, ten SNPs were identified. The most significant association was obtained with SNPs in KCNQ1, rs2237892 in intron 15 showed the lowest Pvalue. The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations. Among control subjects, the risk allele of this polymorphism was associated with impairment of insulin secretion.
Formal Description
Interaction-ID: 22810

increases_activity of

in Japanese, the risk allele is C
Comment In a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, ten SNPs were identified. The most significant association was obtained with SNPs in KCNQ1, rs2237892 in intron 15 showed the lowest Pvalue. The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations. Among control subjects, the risk allele of this polymorphism was associated with impairment of insulin secretion.
Formal Description
Interaction-ID: 22811

increases_activity of

in Japanese, the risk allele is G
Comment In a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, ten SNPs were identified. The most significant association was obtained with SNPs in KCNQ1, rs2237892 in intron 15 showed the lowest Pvalue. The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations. Among control subjects, the risk allele of this polymorphism was associated with impairment of insulin secretion.
Formal Description
Interaction-ID: 22812

increases_activity of

in Japanese, the risk allele is G
Comment In a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, ten SNPs were identified. The most significant association was obtained with SNPs in KCNQ1, rs2237892 in intron 15 showed the lowest Pvalue. The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations. Among control subjects, the risk allele of this polymorphism was associated with impairment of insulin secretion.
Formal Description
Interaction-ID: 22813

increases_activity of

in Japanese, the risk allele is C
Comment In a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, ten SNPs were identified. The most significant association was obtained with SNPs in KCNQ1, rs2237892 in intron 15 showed the lowest Pvalue. The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations. Among control subjects, the risk allele of this polymorphism was associated with impairment of insulin secretion.
Formal Description
Interaction-ID: 22814

increases_activity of

in Japanese, the risk allele is A
Comment In a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, ten SNPs were identified. The most significant association was obtained with SNPs in KCNQ1, rs2237892 in intron 15 showed the lowest Pvalue. The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations. Among control subjects, the risk allele of this polymorphism was associated with impairment of insulin secretion.
Formal Description
Interaction-ID: 22815

decreases_activity of

in pancreas, in pancreatic islets; in Japanese, in Koreans, in Chinese, in Europeans, the risk allele is C
Comment In a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, ten SNPs were identified. The most significant association was obtained with SNPs in KCNQ1, rs2237892 in intron 15 showed the lowest Pvalue. The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations. Among control subjects, the risk allele of this polymorphism was associated with impairment of insulin secretion.
Formal Description
Interaction-ID: 22816

increases_activity of

in Japanese, in Koreans, in Chinese, in Europeans, the risk allele is G
Comment In a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, ten SNPs were identified. The most significant association was obtained with SNPs in KCNQ1, rs2237892 in intron 15 showed the lowest Pvalue. The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations. Among control subjects, the risk allele of this polymorphism was associated with impairment of insulin secretion.
Formal Description
Interaction-ID: 22817

increases_activity of

in Japanese, in Koreans, in Chinese, in Europeans, the risk allele is C