General Information:

Id: 2,417
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
Han Chinese
article
Reference: Liu C et al.(2011) Variants in GLIS3 and CRY2 are associated with type 2 diabetes and impaired fasting glucose in Chinese Hans PLoS ONE 6 [PMID: 21747906]

Interaction Information:

Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21746

affects_activity of

phenotype

hyperglycemia

after fasting, in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21747

decreases_activity of

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21748

NOT affects_activity of

disease

Obesity

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21749

NOT affects_activity of

disease

Insulin resistance

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21750

NOT affects_quantity of

complex/PPI

Glycated hemoglobin

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21751

NOT affects_activity of

phenotype

hyperglycemia

after fasting, in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21752

NOT affects_activity of

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21753

NOT affects_activity of

disease

Obesity

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21754

NOT affects_activity of

disease

Insulin resistance

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21755

NOT affects_quantity of

complex/PPI

Glycated hemoglobin

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21756

NOT affects_activity of

phenotype

hyperglycemia

after fasting, in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21757

NOT affects_activity of

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21758

NOT affects_activity of

disease

Obesity

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21759

NOT affects_activity of

disease

Insulin resistance

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21760

NOT affects_quantity of

complex/PPI

Glycated hemoglobin

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21761

NOT affects_activity of

phenotype

hyperglycemia

after fasting, in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21762

NOT affects_activity of

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21763

NOT affects_activity of

disease

Obesity

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21764

NOT affects_activity of

disease

Insulin resistance

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21765

NOT affects_quantity of

complex/PPI

Glycated hemoglobin

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21766

NOT affects_activity of

phenotype

hyperglycemia

after fasting, in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21767

NOT affects_activity of

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21768

affects_activity of

disease

Obesity

in Han Chinese, the effective allele is C
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21769

NOT affects_activity of

disease

Insulin resistance

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21770

NOT affects_quantity of

complex/PPI

Glycated hemoglobin

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21771

NOT affects_activity of

phenotype

hyperglycemia

after fasting, in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21772

NOT affects_activity of

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21773

NOT affects_activity of

disease

Obesity

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21774

NOT affects_activity of

disease

Insulin resistance

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21775

NOT affects_quantity of

complex/PPI

Glycated hemoglobin

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21776

NOT affects_activity of

phenotype

hyperglycemia

after fasting, in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21777

NOT affects_activity of

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21778

NOT affects_activity of

disease

Obesity

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21779

NOT affects_activity of

disease

Insulin resistance

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21780

NOT affects_quantity of

complex/PPI

Glycated hemoglobin

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21781

NOT affects_activity of

phenotype

hyperglycemia

after fasting, in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21782

NOT affects_activity of

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21783

NOT affects_activity of

disease

Obesity

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21784

NOT affects_activity of

disease

Insulin resistance

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21785

NOT affects_quantity of

complex/PPI

Glycated hemoglobin

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21786

NOT affects_activity of

phenotype

hyperglycemia

after fasting, in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21787

NOT affects_activity of

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21788

NOT affects_activity of

disease

Obesity

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21789

NOT affects_activity of

disease

Insulin resistance

in Han Chinese
Comment GLIS3-rs7034200 showed significant associations with fasting glucose and HOMA-B, but not with BMI, HbA1c or HOMA-IR. None of the remaining eight loci (MADD-rs7944584, ADRA2A-rs10885122, CRY2-rs11605924, PROX1-rs340874, C2CD4B-rs11071657, IGF1-rs35767, IRS1- rs2943641 and FADS1-rs174550) were associated with any of glycemic traits, while a nominal association was observed between PROX1-rs340874 and BMI.
Formal Description
Interaction-ID: 21790

NOT affects_quantity of

complex/PPI

Glycated hemoglobin

in Han Chinese
Comment Of the nine SNPs, GLIS3-rs7034200 was also significantly associated with type 2 diabetes, impaired fasting glucose (IFG), and combined IFG/type 2 diabetes.
Formal Description
Interaction-ID: 21791

increases_activity of

in Han Chinese
Comment The glucose-increasing-(A-) allele of CRY2-rs11605924 was significantly associated with increased risk of combined IFG/type 2 diabetes. Although the associations with type 2 diabetes and IFG showed similar trends, the results did not reach nominal significance. The direction of associations for loci ADRA2A, IGF1 and IRS1 were consistent to those observed in the previous GWAS, however none of the remaining loci were associated with type 2 diabetes, IFG or combined IFG/type 2 diabetes.
Formal Description
Interaction-ID: 21792

NOT affects_activity of

in Han Chinese
Comment The glucose-increasing-(A-) allele of CRY2-rs11605924 was significantly associated with increased risk of combined IFG/type 2 diabetes. Although the associations with type 2 diabetes and IFG showed similar trends, the results did not reach nominal significance. The direction of associations for loci ADRA2A, IGF1 and IRS1 were consistent to those observed in the previous GWAS, however none of the remaining loci were associated with type 2 diabetes, IFG or combined IFG/type 2 diabetes.
Formal Description
Interaction-ID: 21793

NOT affects_activity of

in Han Chinese
Comment The glucose-increasing-(A-) allele of CRY2-rs11605924 was significantly associated with increased risk of combined IFG/type 2 diabetes. Although the associations with type 2 diabetes and IFG showed similar trends, the results did not reach nominal significance. The direction of associations for loci ADRA2A, IGF1 and IRS1 were consistent to those observed in the previous GWAS, however none of the remaining loci were associated with type 2 diabetes, IFG or combined IFG/type 2 diabetes.
Formal Description
Interaction-ID: 21794

NOT affects_activity of

in Han Chinese
Comment The glucose-increasing-(A-) allele of CRY2-rs11605924 was significantly associated with increased risk of combined IFG/type 2 diabetes. Although the associations with type 2 diabetes and IFG showed similar trends, the results did not reach nominal significance. The direction of associations for loci ADRA2A, IGF1 and IRS1 were consistent to those observed in the previous GWAS, however none of the remaining loci were associated with type 2 diabetes, IFG or combined IFG/type 2 diabetes.
Formal Description
Interaction-ID: 21795

NOT affects_activity of

in Han Chinese
Comment The glucose-increasing-(A-) allele of CRY2-rs11605924 was significantly associated with increased risk of combined IFG/type 2 diabetes. Although the associations with type 2 diabetes and IFG showed similar trends, the results did not reach nominal significance. The direction of associations for loci ADRA2A, IGF1 and IRS1 were consistent to those observed in the previous GWAS, however none of the remaining loci were associated with type 2 diabetes, IFG or combined IFG/type 2 diabetes.
Formal Description
Interaction-ID: 21796

NOT affects_activity of

in Han Chinese
Comment The glucose-increasing-(A-) allele of CRY2-rs11605924 was significantly associated with increased risk of combined IFG/type 2 diabetes. Although the associations with type 2 diabetes and IFG showed similar trends, the results did not reach nominal significance. The direction of associations for loci ADRA2A, IGF1 and IRS1 were consistent to those observed in the previous GWAS, however none of the remaining loci were associated with type 2 diabetes, IFG or combined IFG/type 2 diabetes.
Formal Description
Interaction-ID: 21797

NOT affects_activity of

in Han Chinese
Comment The glucose-increasing-(A-) allele of CRY2-rs11605924 was significantly associated with increased risk of combined IFG/type 2 diabetes. Although the associations with type 2 diabetes and IFG showed similar trends, the results did not reach nominal significance. The direction of associations for loci ADRA2A, IGF1 and IRS1 were consistent to those observed in the previous GWAS, however none of the remaining loci were associated with type 2 diabetes, IFG or combined IFG/type 2 diabetes.
Formal Description
Interaction-ID: 21798

NOT affects_activity of

in Han Chinese
Comment The glucose-increasing-(A-) allele of CRY2-rs11605924 was significantly associated with increased risk of combined IFG/type 2 diabetes. Although the associations with type 2 diabetes and IFG showed similar trends, the results did not reach nominal significance. The direction of associations for loci ADRA2A, IGF1 and IRS1 were consistent to those observed in the previous GWAS, however none of the remaining loci were associated with type 2 diabetes, IFG or combined IFG/type 2 diabetes.
Formal Description
Interaction-ID: 21799

NOT affects_activity of

in Han Chinese