General Information:

Id: 2,416
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Boesgaard TW et al.(2010) Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people Diabetologia 53: 1647-1655 [PMID: 20419449]

Interaction Information:

Comment Carriers of the DGKB/TMEM195 rs2191349 glucose-raising T-allele showed decreased glucose-stimulated insulin release.
Formal Description
Interaction-ID: 21742

decreases_activity of

the effective allele is T
Comment Carriers of the glucose-raising G allele of ADRA2A rs10885122 showed a consistent decreased insulin response after oral glucose ingestion.
Formal Description
Interaction-ID: 21743

decreases_activity of

the effective allele is G
Comment Carriers of the glucose-raising A-allele of C2CD4B rs11071657 had a 4.3% decreased insulin release.
Formal Description
Interaction-ID: 21744

decreases_activity of

the effective allele is A
Comment Carriers of the glucose-raising A-allele of GLIS3 rs7034200 had a decreased glucose-stimulated insulin release.
Formal Description
Interaction-ID: 21745

decreases_activity of

the effective allele is A