General Information:

Id: 2,403 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Magnusson I et al.(1992) Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study. J. Clin. Invest. 90: 1323-1327 [PMID: 1401068]

Interaction Information:

Comment To quantitate hepatic glycogenolysis, liver glycogen concentration was measured with 13C nuclear magnetic resonance spectroscopy in seven type II diabetic and five control subjects during 23 h of fasting. Liver glycogen concentration 4 h after a meal was lower in the diabetics than in the controls. Net hepatic glycogenolysis was decreased in the diabetics. Whole body glucose production was increased in the diabetics as compared to the controls. Gluconeogenesis was consequently increased in the diabetics and accounted for 88 % of total glucose production as compared with 70 % in the controls. In conclusion: increased gluconeogenesis is responsible for the increased whole body glucose production in type II diabetes mellitus after an overnight fast.
Formal Description
Interaction-ID: 21406

increases_activity of

process

gluconeogenesis

in liver