General Information:

Id: 238
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1(G93A) transgenic mouse
BTO:0001279 spinal cord
article
Reference: Ying Z et al.(2009) Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation Hum. Mol. Genet. 18: 4268-4281 [PMID: 19661182]

Interaction Information:

Comment Mutant SOD1 upregulates endogenous gp78 by triggering ER stress. In spinal cords of SOD1G93A transgenic mice gp78 was significantly increased.
Formal Description
Interaction-ID: 986

gene/protein mutant

SOD1-p.G93A

increases_quantity of

gene/protein

AMFR

Comment In spinal cords of SOD1G93A transgenic mice, gp78 was colocalized onto the SOD1 aggregates and the ubiquitinated aggregates.
Formal Description
Interaction-ID: 13347

gene/protein

AMFR

interacts (colocalizes) with

phenotype

SOD1 protein aggregates

in SOD1G93A transgenic mice
Comment Mutant SOD1 induces aggregate formation. In spinal cords of SOD1G93A transgenic mice, gp78 was colocalized onto the SOD1 aggregates and the ubiquitinated aggregates.
Formal Description
Interaction-ID: 13348

gene/protein mutant

SOD1-p.G93A

increases_quantity of

phenotype

SOD1 protein aggregates