General Information:

Id: 2,371
Diseases: Alzheimer disease - [OMIM]
Canis lupus familiaris
aged beagle
brain
article
Reference: Barone E et al.(2011) Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action Pharmacol. Res. 63: 172-180 [PMID: 21193043]

Interaction Information:

Comment Atorvastatin significantly reduced lipoperoxidation, protein oxidation and nitration, and increased GSH levels in parietal cortex of aged beagles.
Formal Description
Interaction-ID: 20808

drug/chemical compound

Atorvastatin

decreases_activity of

process

lipid peroxidation

in parietal cortex of aged beagles
Drugbank entries Show/Hide entries for Atorvastatin
Comment Atorvastatin significantly reduced lipoperoxidation, protein oxidation and nitration, and increased GSH levels in parietal cortex of aged beagles.
Formal Description
Interaction-ID: 20810

drug/chemical compound

Atorvastatin

decreases_activity of

in parietal cortex of aged beagles
Drugbank entries Show/Hide entries for Atorvastatin
Comment Atorvastatin significantly reduced lipoperoxidation, protein oxidation and nitration, and increased GSH levels in parietal cortex of aged beagles.
Formal Description
Interaction-ID: 20812

drug/chemical compound

Atorvastatin

decreases_activity of

in parietal cortex of aged beagles
Drugbank entries Show/Hide entries for Atorvastatin
Comment Atorvastatin significantly reduced lipoperoxidation, protein oxidation and nitration, and increased GSH levels in parietal cortex of aged beagles.
Formal Description
Interaction-ID: 20813

drug/chemical compound

Atorvastatin

increases_quantity of

drug/chemical compound

Glutathione

in parietal cortex of aged beagles
Drugbank entries Show/Hide entries for Atorvastatin or Glutathione
Comment Atorvastatin slightly reduced the formation of cholesterol oxidation products in cortex but increased the 7-ketocholesterol/total cholesterol ratio in serum.
Formal Description
Interaction-ID: 20814

drug/chemical compound

Atorvastatin

affects_activity of

in cortex; formation of cholesterol oxidation products was affected
Drugbank entries Show/Hide entries for Atorvastatin
Comment Increased oxidative damage in the parietal cortex was associated with poorer learning (visual discrimination task).
Formal Description
Interaction-ID: 20815

affects_activity of

process

visual learning

in parietal cortex of aged beagles