General Information:

Id: 236
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
genetic association study of AD cohorts
article
Reference: Moore CK et al.(1991) Cardiac allograft cellular rejection during OKT3 prophylaxis in the absence of sensitization Transplant. Proc. 23: 1055-1058 [PMID: 1899151]

Interaction Information:

Comment Consistent interaction between GSK3B and MAPT genes in three late-onset AD cohorts was observed.
Formal Description
Interaction-ID: 980

gene/protein

GSK3B

interacts (colocalizes) with

gene/protein

MAPT

Drugbank entries Show/Hide entries for GSK3B
Comment Overexpression of either MAPT or GSK3B resulted in decreased beta-catenin levels.
Formal Description
Interaction-ID: 981

gene/protein

MAPT

decreases_expression of

gene/protein

CTNNB1

if MAPT is overexpressed
Drugbank entries Show/Hide entries for CTNNB1
Comment Overexpression of either MAPT or GSK3B resulted in decreased beta-catenin levels.
Formal Description
Interaction-ID: 984

gene/protein

GSK3B

decreases_expression of

gene/protein

CTNNB1

if GSK3B is overexpressed
Drugbank entries Show/Hide entries for GSK3B or CTNNB1
Comment Cotransfection of both - of GSK3B and MAPT - increased beta-catenin signaling.
Formal Description
Interaction-ID: 985

gene/protein

GSK3B

increases_activity of

gene/protein

CTNNB1

if cotranfected with MAPT
Drugbank entries Show/Hide entries for GSK3B or CTNNB1
Comment Cotransfection of both - of GSK3B and MAPT - increased beta-catenin signaling.
Formal Description
Interaction-ID: 14039

gene/protein

MAPT

increases_activity of

gene/protein

CTNNB1

if cotranfected with GSK3B
Drugbank entries Show/Hide entries for CTNNB1