General Information:

Id: 2,278 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Heneka MT et al.(2011) Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimers disease. Curr Alzheimer Res 8: 115-131 [PMID: 21345168]

Interaction Information:

Comment Abeta42 levels were only significantly lowered for ibuprofen treated animals, but a trend was observed for pioglitazone.
Formal Description
Interaction-ID: 19533

drug/chemical compound

Ibuprofen

decreases_quantity of

Drugbank entries Show/Hide entries for Ibuprofen
Comment Early GSMs (gamma-secretase modulators), such as ibuprofen and indomethacin belong to the NSAID (non-steroidal anti-inflammatory drug) compound class.
Formal Description
Interaction-ID: 27842

drug/chemical compound

Ibuprofen

affects_activity of

Drugbank entries Show/Hide entries for Ibuprofen
Comment A subset of NSAIDs (Non-steroid antiinflammatory drugs), including ibuprofen, indomethacin, and sulindac sulfide, was observed to either selectively reduce Abeta 42 production with a concomitant increase in Abeta 38 levels or vice versa and were thus renamed gamma-secretase modulators (GSM)
Formal Description
Interaction-ID: 28156

drug/chemical compound

Ibuprofen

affects_quantity of

Drugbank entries Show/Hide entries for Ibuprofen
Comment A subset of NSAIDs (Non-steroid antiinflammatory drugs), including ibuprofen, indomethacin, and sulindac sulfide, was observed to either selectively reduce Abeta 42 production with a concomitant increase in Abeta 38 levels or vice versa and were thus renamed gamma-secretase modulators (GSM)
Formal Description
Interaction-ID: 28158

drug/chemical compound

Ibuprofen

affects_quantity of

Drugbank entries Show/Hide entries for Ibuprofen