General Information:

Id: 2,278 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Heneka MT et al.(2011) Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimers disease. Curr Alzheimer Res 8: 115-131 [PMID: 21345168]

Interaction Information:

Comment The intake of non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk and delay the onset of AD. But neither the ideal time point for treatment, nor the exact mechanism of interaction has yet been identified. Some therapeutic studies testing NSAID efficacy in AD patients have not yielded positive results.
Formal Description
Interaction-ID: 19437

drug/chemical compound

NSAID

decreases_activity of

Comment The intake of non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk and delay the onset of AD. But neither the ideal time point for treatment, nor the exact mechanism of interaction has yet been identified. Some therapeutic studies testing NSAID efficacy in AD patients have not yielded positive results.
Formal Description
Interaction-ID: 19438

drug/chemical compound

NSAID

decreases_activity of

Comment NSAID (Non-steroid antiinflammatory drug) is able to activate the receptor PPAR-gamma.
Formal Description
Interaction-ID: 19473

drug/chemical compound

NSAID

increases_activity of

gene/protein

PPARG

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Comment The canonical targets of all NSAIDs (Non-steroid antiinflammatory drugs) are both isoforms of cyclooxygenase, COX-1 and COX-2.
Formal Description
Interaction-ID: 19598

drug/chemical compound

NSAID

affects_activity of

gene/protein

PTGS1

Drugbank entries Show/Hide entries for PTGS1
Comment The canonical targets of all NSAIDs (Non-steroid antiinflammatory drugs) are both isoforms of cyclooxygenase, COX-1 and COX-2.
Formal Description
Interaction-ID: 19617

drug/chemical compound

NSAID

affects_activity of

gene/protein

PTGS2

Drugbank entries Show/Hide entries for PTGS2