General Information:
Id: | 2,273 (click here to show other Interactions for entry) |
Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
Mus musculus | |
ENU-induced point mutations in Nnt N68K and G745D | |
article | |
Reference: | Freeman H et al.(2006) Nicotinamide nucleotide transhydrogenase: a key role in insulin secretion. Cell Metab. 3: 35-45 [PMID: 16399503] |
Interaction Information:
Comment | Two ENU-induced point mutations in Nnt (N68K, G745D) were identified. Nnt mutant mice were glucose intolerant and secreted less insulin during a glucose tolerance test. Isolated islets showed impaired insulin secretion in response to glucose, but not to tolbutamide, and glucose failed to enhance ATP levels. |
Formal Description Interaction-ID: 19412 |
gene/protein mutant affects_activity of process |
Comment | Two ENU-induced point mutations in Nnt (N68K, G745D) were identified. Nnt mutant mice were glucose intolerant and secreted less insulin during a glucose tolerance test. Isolated islets showed impaired insulin secretion in response to glucose, but not to tolbutamide, and glucose failed to enhance ATP levels. |
Formal Description Interaction-ID: 19415 |
gene/protein mutant affects_activity of process |