General Information:

Id: 2,270
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
male
VLCAD-/- mouse, LCAD-/- mouse
article
Reference: Zhang D et al.(2010) Resistance to high-fat diet-induced obesity and insulin resistance in mice with very long-chain acyl-CoA dehydrogenase deficiency. Cell Metab. 11: 402-411 [PMID: 20444420]

Interaction Information:

Comment Mitochondrial fatty acid oxidation provides an important energy source for cellular metabolism, and decreased mitochondrial fatty acid oxidation has been implicated in the pathogenesis of type 2 diabetes. Paradoxically, mice with an inherited deficiency of the mitochondrial fatty acid oxidation enzyme, very long-chain acyl-CoA dehydrogenase (VLCAD), were protected from high-fat diet-induced obesity and liver and muscle insulin resistance.
Formal Description
Interaction-ID: 19377

gene/protein

ACADVL

affects_activity of

phenotype

obesity, high-fat diet-induced

Comment Mitochondrial fatty acid oxidation provides an important energy source for cellular metabolism, and decreased mitochondrial fatty acid oxidation has been implicated in the pathogenesis of type 2 diabetes. Paradoxically, mice with an inherited deficiency of the mitochondrial fatty acid oxidation enzyme, very long-chain acyl-CoA dehydrogenase (VLCAD), were protected from high-fat diet-induced obesity and liver and muscle insulin resistance.
Formal Description
Interaction-ID: 19379

gene/protein

ACADVL

affects_activity of

disease

Insulin resistance

in liver, in muscle
Comment Mice with an inherited deficiency of the mitochondrial fatty acid oxidation enzyme, very long-chain acyl-CoA dehydrogenase (VLCAD) had reduced intracellular diacylglycerol content and decreased activity of liver protein kinase C var epsilon and muscle protein kinase C theta.
Formal Description
Interaction-ID: 19380

gene/protein

ACADVL

affects_quantity of

drug/chemical compound

Diacylglycerol

in muscle, in liver
Comment Mice with an inherited deficiency of the mitochondrial fatty acid oxidation enzyme, very long-chain acyl-CoA dehydrogenase (VLCAD) had reduced intracellular diacylglycerol content and decreased activity of liver protein kinase C var epsilon and muscle protein kinase C theta.
Formal Description
Interaction-ID: 19382

gene/protein

ACADVL

affects_activity of

gene/protein

PRKCE

in liver
Comment Mice with an inherited deficiency of the mitochondrial fatty acid oxidation enzyme, very long-chain acyl-CoA dehydrogenase (VLCAD) had reduced intracellular diacylglycerol content and decreased activity of liver protein kinase C var epsilon and muscle protein kinase C theta.
Formal Description
Interaction-ID: 19383

gene/protein

ACADVL

affects_activity of

gene/protein

PRKCQ

in muscle
Drugbank entries Show/Hide entries for PRKCQ
Comment The increased insulin sensitivity in the VLCAD(-/-) mice were protected from diet-induced obesity and insulin resistance due to chronic activation of AMPK and PPARalpha, resulting in increased fatty acid oxidation and decreased intramyocellular and hepatocellular diacylglycerol content.
Formal Description
Interaction-ID: 19399

gene/protein

ACADVL

affects_activity of

phenotype

obesity, high-fat diet-induced

Comment The increased insulin sensitivity in the VLCAD(-/-) mice were protected from diet-induced obesity and insulin resistance due to chronic activation of AMPK and PPARalpha, resulting in increased fatty acid oxidation and decreased intramyocellular and hepatocellular diacylglycerol content.
Formal Description
Interaction-ID: 19400

gene/protein

ACADVL

affects_activity of

complex/PPI

AMPK

Comment The increased insulin sensitivity in the VLCAD(-/-) mice were protected from diet-induced obesity and insulin resistance due to chronic activation of AMPK and PPARalpha, resulting in increased fatty acid oxidation and decreased intramyocellular and hepatocellular diacylglycerol content.
Formal Description
Interaction-ID: 19401

gene/protein

ACADVL

affects_activity of

gene/protein

PPARA

Drugbank entries Show/Hide entries for PPARA
Comment The increased insulin sensitivity in the VLCAD(-/-) mice were protected from diet-induced obesity and insulin resistance due to chronic activation of AMPK and PPARalpha, resulting in increased fatty acid oxidation and decreased intramyocellular and hepatocellular diacylglycerol content.
Formal Description
Interaction-ID: 19402

gene/protein

ACADVL

affects_activity of