General Information:

Id: 2,269 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Canis lupus familiaris
article
Reference: Murphy MP et al.(2010) Changes in cognition and amyloid-beta processing with long term cholesterol reduction using atorvastatin in aged dogs. J. Alzheimers Dis. 22: 135-150 [PMID: 20847439]

Interaction Information:

Comment Spatial memory function in aged dogs did not change with atorvastatin treatment.
Formal Description
Interaction-ID: 19373

drug/chemical compound

Atorvastatin

NOT increases_activity of

process

memory

in aged dogs
Drugbank entries Show/Hide entries for Atorvastatin
Comment Peripheral levels of cholesterol, LDLs, triglycerides, and HDL were significantly reduced in atorvastatin treated aged dogs.
Formal Description
Interaction-ID: 19388

drug/chemical compound

Atorvastatin

decreases_quantity of

complex/PPI

LDL

in aged dogs
Drugbank entries Show/Hide entries for Atorvastatin
Comment Peripheral levels of cholesterol, LDLs, triglycerides, and HDL were significantly reduced in atorvastatin treated aged dogs.
Formal Description
Interaction-ID: 19389

drug/chemical compound

Atorvastatin

decreases_quantity of

complex/PPI

HDL

in aged dogs
Drugbank entries Show/Hide entries for Atorvastatin
Comment Peripheral levels of cholesterol, LDLs, triglycerides, and HDL were significantly reduced in atorvastatin treated aged dogs.
Formal Description
Interaction-ID: 19390

drug/chemical compound

Atorvastatin

decreases_quantity of

drug/chemical compound

Triacylglycerol

in aged dogs
Drugbank entries Show/Hide entries for Atorvastatin
Comment Peripheral levels of cholesterol, LDLs, triglycerides, and HDL were significantly reduced in atorvastatin treated aged dogs.
Formal Description
Interaction-ID: 19391

drug/chemical compound

Atorvastatin

decreases_quantity of

drug/chemical compound

Cholesterol

in aged dogs
Drugbank entries Show/Hide entries for Atorvastatin or Cholesterol
Comment Lipidomic analysis revealed a significant decrease in the ratio of omega-6 to omega-3 essential fatty in temporal cortex of atorvastatin treated aged dogs.
Formal Description
Interaction-ID: 19405

drug/chemical compound

Atorvastatin

affects_quantity of

drug/chemical compound

Omega-6 fatty acid

CHEBI: 36009 omega-6 fatty acid
Drugbank entries Show/Hide entries for Atorvastatin
Comment Lipidomic analysis revealed a significant decrease in the ratio of omega-6 to omega-3 essential fatty in temporal cortex of atorvastatin treated aged dogs.
Formal Description
Interaction-ID: 19407

drug/chemical compound

Atorvastatin

affects_quantity of

drug/chemical compound

Omega-3 fatty acid

CHEBI: 25681 omega-3 fatty acid
Drugbank entries Show/Hide entries for Atorvastatin
Comment No change in total A PP was detected in atorvastatin treated aged dogs.
Formal Description
Interaction-ID: 19411

drug/chemical compound

Atorvastatin

NOT affects_quantity of

gene/protein

APP

Drugbank entries Show/Hide entries for Atorvastatin or APP