General Information:

Id: 2,266 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Obesity - [OMIM]
Mus musculus
male
SPP1 -/- mouse (OPN-/-)
article
Reference: Kiefer FW et al.(2011) Osteopontin deficiency protects against obesity-induced hepatic steatosis and attenuates glucose production in mice. Diabetologia 54: 2132-2142 [PMID: 21562757]

Interaction Information:

Comment Neither was enhanced fatty acid oxidation likely to contribute to reduced hepatic steatosis since important transcription factors driving beta-oxidation were unchanged or even downregulated as shown for Ppara and Ppargc1a, respectively.
Formal Description
Interaction-ID: 19349

gene/protein

SPP1

NOT affects_expression of

gene/protein

PPARA

in liver
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