General Information:

Id: 2,261
Diseases: Neurological
Schizophrenia - [OMIM]
Mus musculus
article
Reference: Beaulieu JM et al.(2005) An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 122: 261-273 [PMID: 16051150]

Interaction Information:

Comment The mice lacking both Arr2 and the DAT (dopamine transporter) do not display an inhibitory action of excessive DA (dopamine) on Akt phosphorylation. This demonstrates that D2R dopamine receptors regulate Akt through Arr2.
Formal Description
Interaction-ID: 19304

gene/protein

ARRB2

decreases_activity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1
Comment The mice lacking both Arr2 and the DAT (dopamine transporter) do not display an inhibitory action of excessive DA (dopamine) on Akt phosphorylation. This demonstrates that D2R dopamine receptors regulate Akt through Arr2.
Formal Description
Interaction-ID: 19305

gene/protein

DRD2

affects_activity of

gene/protein

ARRB2

Drugbank entries Show/Hide entries for DRD2
Comment The interaction of Akt and PP2A subunits with beta-arrestin 2 occurs in the mouse striatum.
Formal Description
Interaction-ID: 19306

gene/protein

AKT1

interacts (colocalizes) with

gene/protein

PPP2R4

Drugbank entries Show/Hide entries for AKT1
Comment The interaction of Akt and PP2A complex with beta-arrestin 2 occurs in the mouse striatum.
Formal Description
Interaction-ID: 19307

complex/PPI

AKT1-PP2A complex

interacts (colocalizes) with

gene/protein

ARRB2