General Information:

Id: 2,249 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Dementia
Mammalia
review
Reference: Butterfield DA et al.(2011) Cholesterol-independent neuroprotective and neurotoxic activities of statins: perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders Pharmacol. Res. 64: 180-186 [PMID: 21536132]

Interaction Information:

Comment The CLASP study was designed to evaluate the neuroprotective role of simvastatin for 18 months in mild-moderate AD patients. It failed to demonstrate a therapeutic role for simvastatin.
Formal Description
Interaction-ID: 19279

drug/chemical compound

Simvastatin

NOT decreases_activity of

(CLASP study)
Drugbank entries Show/Hide entries for Simvastatin