General Information:

Id: 2,249 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Dementia
Mammalia
review
Reference: Butterfield DA et al.(2011) Cholesterol-independent neuroprotective and neurotoxic activities of statins: perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders Pharmacol. Res. 64: 180-186 [PMID: 21536132]

Interaction Information:

Comment Atorvastatin treatment was neuroprotective against cell degeneration induced by Abeta (1-40), reducing inflammatory and oxidative responses and increasing the expression of glutamatergic transporters.
Formal Description
Interaction-ID: 19227

drug/chemical compound

Atorvastatin

decreases_activity of

phenotype

neurodegeneration

neuroprotection against cell degeneration induced by Abeta (1-40)
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Comment Atorvastatin treatment was neuroprotective against cell degeneration induced by Abeta (1-40), reducing inflammatory and oxidative responses and increasing the expression of glutamatergic transporters.
Formal Description
Interaction-ID: 19228

drug/chemical compound

Atorvastatin

decreases_activity of

Drugbank entries Show/Hide entries for Atorvastatin
Comment Atorvastatin treatment was neuroprotective against cell degeneration induced by Abeta (1-40), reducing inflammatory and oxidative responses and increasing the expression of glutamatergic transporters.
Formal Description
Interaction-ID: 19229

drug/chemical compound

Atorvastatin

decreases_activity of

Drugbank entries Show/Hide entries for Atorvastatin
Comment Atorvastatin treatment was neuroprotective against cell degeneration induced by Abeta (1-40), reducing inflammatory and oxidative responses and increasing the expression of glutamatergic transporters.
Formal Description
Interaction-ID: 19230

drug/chemical compound

Atorvastatin

increases_expression of

gene/protein

Glutamatergic transporter

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Comment Long-term atorvastatin did not affect Abeta levels, despite a significant reduction in beta-secretase 1 (BACE1) protein levels and activity in the brain of aged beagles.
Formal Description
Interaction-ID: 19233

drug/chemical compound

Atorvastatin

NOT affects_quantity of

gene/protein

Amyloid beta peptide

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Comment Long-term atorvastatin did not affect Abeta levels, despite a significant reduction in beta-secretase 1 (BACE1) protein levels.
Formal Description
Interaction-ID: 19236

drug/chemical compound

Atorvastatin

decreases_quantity of

gene/protein

BACE1

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Comment Long-term atorvastatin significantly reduced lipoperoxidation, protein oxidation and nitration, and increased GSH levels in parietal cortex of the same animals.
Formal Description
Interaction-ID: 19237

drug/chemical compound

Atorvastatin

decreases_activity of

process

lipid peroxidation

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Comment Long-term atorvastatin significantly reduced lipoperoxidation, protein oxidation and nitration, and increased GSH levels in parietal cortex of the same animals.
Formal Description
Interaction-ID: 19252

drug/chemical compound

Atorvastatin

decreases_activity of

Drugbank entries Show/Hide entries for Atorvastatin
Comment Long-term atorvastatin significantly reduced lipoperoxidation, protein oxidation and nitration, and increased GSH levels in parietal cortex of the same animals.
Formal Description
Interaction-ID: 19253

drug/chemical compound

Atorvastatin

decreases_activity of

Drugbank entries Show/Hide entries for Atorvastatin
Comment Long-term atorvastatin significantly reduced lipoperoxidation, protein oxidation and nitration, and increased GSH levels in parietal cortex of the same animals.
Formal Description
Interaction-ID: 19254

drug/chemical compound

Atorvastatin

increases_quantity of

drug/chemical compound

Glutathione

cholesterol- and Abeta-independent and specific for brain
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Comment Side effects of long-term statin treatment atorvastatin with include a decrease in CoQ10 levels resulting in energy metabolism impairment in heart, skeletal muscle, and liver.
Formal Description
Interaction-ID: 19256

drug/chemical compound

Atorvastatin

decreases_quantity of

drug/chemical compound

Ubichinon-10

(side effects of long-term statin treatment)
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Comment Side effects of long-term statin treatment atorvastatin with include a decrease in CoQ10 levels resulting in energy metabolism impairment in heart, skeletal muscle, and liver.
Formal Description
Interaction-ID: 19259

drug/chemical compound

Atorvastatin

increases_activity of

in heart, skeletal muscle, and liver; (as side effect of long-term statin treatment)
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Comment The LEADe study did not support any significant positive effect of atorvastatin on cognitive or global functions in patients receiving the statin compared to those with placebo.
Formal Description
Interaction-ID: 19270

drug/chemical compound

Atorvastatin

NOT decreases_activity of

phenotype

cognitive impairment

(LEADe study)
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Comment The ADCLT trial demonstrated that atorvastatin for 1 year exhibited a significant positive effect on cognitive performance after 6 months of therapy compared with placebo.
Formal Description
Interaction-ID: 19280

drug/chemical compound

Atorvastatin

decreases_activity of

phenotype

cognitive impairment

(ADCLT trial)
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