General Information:

Id: 2,249 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Dementia
Mammalia
review
Reference: Butterfield DA et al.(2011) Cholesterol-independent neuroprotective and neurotoxic activities of statins: perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders Pharmacol. Res. 64: 180-186 [PMID: 21536132]

Interaction Information:

Comment Statins showed positive effects against Alzheimer-relevant Abeta-induced oxidative stress in mice models of AD as well as a reduction in CSF tau protein phosphorylation in humans.
Formal Description
Interaction-ID: 19214

drug/chemical compound

Statin

decreases_phosphorylation of

gene/protein

MAPT

in CFS; of patients, Alzheimer-relevant and Abeta-induced