General Information:

Id: 2,245
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Carlsson CM(2010) Type 2 diabetes mellitus, dyslipidemia, and Alzheimers disease. J. Alzheimers Dis. 20: 711-722 [PMID: 20413858]

Interaction Information:

Comment Midlife vascular risk factors, including type 2 diabetes mellitus (T2DM), have been associated with increased risk of AD decades later.
Formal Description
Interaction-ID: 19169

increases_activity of

Comment Hypothesis: T2DM and hyperinsulinemia increase risk for AD, possibly through their effects on amyloid-beta metabolism and cerebrovascular dysfunction - two early findings in preclinical AD pathology.
Formal Description
Interaction-ID: 19170

none selected

Drugbank entries Show/Hide entries for or
Comment High serum total cholesterol levels have been associated with increased risk of AD.
Formal Description
Interaction-ID: 19171

drug/chemical compound

Cholesterol

increases_activity of

concerning serum total cholesterol level
Drugbank entries Show/Hide entries for Cholesterol
Comment T2DM is associated with a dyslipidemia characterized by hypertriglyceridemia, low HDL-cholesterol levels, and small, dense low-density lipoprotein (LDL) particles.
Formal Description
Interaction-ID: 19329

increases_activity of

Comment T2DM is associated with a dyslipidemia characterized by hypertriglyceridemia, low HDL-cholesterol levels, and small, dense low-density lipoprotein (LDL) particles.
Formal Description
Interaction-ID: 19330

cooccurs with

Comment T2DM is associated with a dyslipidemia characterized by hypertriglyceridemia, low HDL-cholesterol levels, and small, dense low-density lipoprotein (LDL) particles.
Formal Description
Interaction-ID: 19331
Comment T2DM, hyperinsulinemia, and dyslipidemia all contribute to abnormal Abeta metabolism, endothelial dysfunction, and increased arterial stiffness - central components of cerebrovascular dysfunction.
Formal Description
Interaction-ID: 19332

increases_activity of

phenotype

abnormal Abeta metabolism

Comment T2DM, hyperinsulinemia, and dyslipidemia all contribute to abnormal Abeta metabolism, endothelial dysfunction, and increased arterial stiffness - central components of cerebrovascular dysfunction.
Formal Description
Interaction-ID: 25965

increases_activity of

phenotype

abnormal Abeta metabolism

Comment T2DM, hyperinsulinemia, and dyslipidemia all contribute to abnormal Abeta metabolism, endothelial dysfunction, and increased arterial stiffness - central components of cerebrovascular dysfunction.
Formal Description
Interaction-ID: 25966

increases_activity of

phenotype

abnormal Abeta metabolism