General Information:

Id: 222 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
SOD1G85R or SOD1G93A transgenic cells
BTO:0000007 HEK-293 cell
article
Reference: Ying Z et al.(2009) Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation. Hum. Mol. Genet. 18: 4268-4281 [PMID: 19661182]

Interaction Information:

Comment Gp78 interacts with and ubiquitinates SOD1, but more ubiquitinated mutant SOD1 (SOD1G85R, SOD1G93A) than wild-type SOD1 was observed.
Formal Description
Interaction-ID: 13337

gene/protein

AMFR

increases_ubiquitination/sumoylation of

gene/protein mutant

SOD1-p.G93A