General Information:

Id: 218 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1 wt or SOD1G93A transgenic mouse, transfected with human wt SOD1 or human SOD1G93A
BTO:0001279 spinal cord
article
Reference: Atkin JD et al.(2006) Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1 J. Biol. Chem. 281 [PMID: 16847061]

Interaction Information:

Comment SOD1(G93A) mice induced the activation of caspase-12 at postnatal day 90 (p90) and disease end stage p120.
Formal Description
Interaction-ID: 895

gene/protein mutant

SOD1-p.G93A

increases_activity of

gene/protein

CASP12

at stage p90 and disease end stage p120